Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda

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dc.contributor.author Kuete, Victor
dc.contributor.author Azebaze, A.G.B.
dc.contributor.author Mbaveng, Armelle T.
dc.contributor.author Nguemfo, E.L.
dc.contributor.author Tshikalange, Thilivhali Emmanuel
dc.contributor.author Chalard, P.
dc.contributor.author Nkengfack, Augustin E.
dc.date.accessioned 2011-04-28T06:48:59Z
dc.date.available 2011-04-28T06:48:59Z
dc.date.issued 2011-01
dc.description.abstract CONTEXT: Allanblackia floribunda Oliver (Guttiferae) is an African medicinal plant used traditionally to treat a variety of ailments. OBJECTIVE: We investigated the antitumor, radical scavenging, antimycobacterial, antibacterial and antifungal activities of the root bark extract of A. floribunda and three isolated phenolics, namely 1,7-dihydroxyxanthone (1), morelloflavone (2) and 7′-O-glucoside of morelloflavone (3). MATERIALS AND METHODS: The 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging assay was used for antioxidant tests, while crown gall tumor assay was used for assay of antitumor activity. The p-iodonitrotetrazolium chloride (INT) colorimetry and Microplate Alamar Blue Assay (MABA) were used for antimicrobial investigations. RESUSLTS: Moderate tumor reducing activity was observed with the extract, while better activities were recorded with compounds 2 and 3. The antimycobacterial and antitumor activities of the extract are being reported for the first time. The DPPH radical scavenging test showed that all the studied samples were able to scavenge more than 50% of the free radical, with compound 3 showing the best inhibitory activity (IC50 of 49.08 µg/mL). Compounds 1 to 3 prevented the growth of Mycobacterium smegmatis and both extract and compound 2 were active on M. tuberculosis. The lowest MIC value for the extract (9.76 μg/mL) was recorded against Enterobacter aerogenes while the corresponding value for the compounds (4.88 µg/mL) was obtained with compound 2 on Trichophyton rubrum. DISCUSSION AND CONCLUSION: The overall results of the present work provide baseline information for the potential use of the root bark extract of A. floribunda as an antimicrobial, antitumor and antioxidant phytomedicine. en
dc.description.sponsorship Authors acknowledge the financial support of the International Foundation for Science (IFS) (Grant no. F /4579-1 to VK) for the antimycobacterial assays and both IFS and the Organization for the Prohibition of Chemical Weapons, The Hague, Netherlands (OPCW),grant F/3969 to AAGB, and the technical support of Mr. P. Lunga of the University of Dschang. en_US
dc.identifier.citation Kuete, V, Azebaze, AGB, Mbaveng, AT, Nguemfo, EL, Tshikalange, ET, Chalard P & Nkengfack, AE 2011, 'Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda', Pharmaceutical Biology, vol. 49, no. 1, pp. 57-65. [http://www.tandf.co.uk/journals/titles/13880209.asp] en
dc.identifier.issn 1388-0209 (print)
dc.identifier.issn 1744-5116 (online)
dc.identifier.other 10.3109/13880209.2010.494673
dc.identifier.uri http://hdl.handle.net/2263/16357
dc.language.iso en en_US
dc.publisher Routledge en_US
dc.rights © Taylor & Francis. This is an electronic version of an article published in Pharmaceutical Biology, vol. 49, no. 1, pp. 57-65, January 2011. Pharmaceutical Biology is available online at: http://www.informaworld.com. en_US
dc.subject Allanblackia floribunda en
dc.subject Antitumor activity en
dc.subject Antimicrobial activities en
dc.subject.lcsh Guttiferae en
dc.subject.lcsh Medicinal plants -- Africa en
dc.subject.lcsh Antioxidants en
dc.subject.lcsh Plant extracts en
dc.title Antioxidant, antitumor and antimicrobial activities of the crude extract and compounds of the root bark of Allanblackia floribunda en
dc.type Postprint Article en


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