Potassium humate inhibits carrageenan induced paw oedema and a graft-vs-host reaction in rats

Show simple item record

dc.contributor.author Naude, P.J.W. (Petrus Johan Wichardt)
dc.contributor.author Cromarty, Allan Duncan
dc.contributor.author Jansen van Rensburg, Constance Elizabeth
dc.date.accessioned 2011-03-07T13:29:43Z
dc.date.available 2011-03-07T13:29:43Z
dc.date.issued 2010-02
dc.description.abstract It has been shown in a previous study that brown coal-derived potassium humate is safe and effective in suppressing contact hypersensitivity in rats. In this study the efficacy of potassium humate on other types of inflammation was determined. Preparative TLC followed by mass spectroscopy was used in an attempt to fingerprint the product. The effects of potassium humate, at an oral dose of 60 mg/kg bodyweight, on a delayed type hypersensitivity reaction, a carrageenan-induced inflammation model and an allogeneic graft-versus-host reaction (GVHR) in rats were investigated. Paw oedema was used as a measure of inflammation. It was found that potassium humate had no effect on the delayed type hypersensitivity reaction but significantly inhibited the increase in paw volume of the carrageenan-induced oedema in rats which compared favourably with indomethacin treatment. Furthermore, potassium humate inhibited the GVHR induced in normal and cyclophosphamide-treated immune-incompetent rats. The identification of a naturally occurring compound that is safe and effective in reducing different types of inflammation merits further evaluation in clinical trials. en_US
dc.description.sponsorship This research was supported by Unique Health Trust and a grant from the South African National Research Foundation (NRF). en_US
dc.identifier.citation Naudé, PJW, Cromarty, AD & Jansen van Rensburg, CE 2010, 'Potassium humate inhibits carrageenan induced paw oedema and a graft-vs-host reaction in rats', Inflammopharmacology, vol. 18, no. 1, pp. 33-39, doi: 10.1007/s10787-009-0026-8. [http://www.springerlink.com/content/103057/] en_US
dc.identifier.issn 0925-4692
dc.identifier.issn 1568-5608 (online)
dc.identifier.other 10.1007/s10787-009-0026-8
dc.identifier.uri http://hdl.handle.net/2263/15982
dc.language.iso en en_US
dc.publisher Springer en_US
dc.rights © Birkhäuser Verlag, Basel/Switzerland 2010. The original publication is available at www.springerlink.com en_US
dc.subject Potassium humate en_US
dc.subject Graft-versus-host reaction en_US
dc.subject Anti-inflammatory en_US
dc.subject Carrageenan-induced inflammation en_US
dc.subject Rats en_US
dc.subject.lcsh Potassium -- Research en
dc.subject.lcsh Anti-inflammatory agents -- South Africa en
dc.title Potassium humate inhibits carrageenan induced paw oedema and a graft-vs-host reaction in rats en_US
dc.type Postprint Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record