Cytotoxicity activity of isolated compounds from Elaeodendron transvaalense ethanol extract
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Date
Authors
Tshikalange, Thilivhali Emmanuel
Hussein, Ahmed A.
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Journals
Abstract
Five known compounds, four triterpenoids and 4’ –O- methylepigallocatechin 5 were isolated from
Elaeodendron transvaalense bark ethanol extract. This plant is traditionally used in Southern Africa for
the treatment of various ailments including sexually associated diseases. Cytotoxicity of the isolated
compounds was determined using XTT colorimetric assay against Vero and MCF-7 breast cancer cell
lines. Compound 1, 3, 4, 5 showed weaker activities with the IC50 ranging from 66.6 to over 100.00 g/ml
in both cell lines. Compound 2 exhibited a good cytotoxicity activity IC50 value of 25.1 for Vero cells and
19.4 for breast cancer cell line.
Description
Keywords
Elaeodendron transvaalense, Cytotoxicity activity, Triterpenoid
Sustainable Development Goals
Citation
Tshikalange, TE & Hussein, A 2010, 'Cytotoxicity activity of isolated compounds from Elaeodendron transvaalense ethanol extract', Journal of Medicinal Plant Research, vol. 4, no. 16, pp. 1695-1697. [www.academicjournals.org/JMPR]