Association between HIV replication and serum leptin levels : an observational study of a cohort of HIV-1-infected South African women

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dc.contributor.author Azzoni, Livio
dc.contributor.author Crowther, Nigel J.
dc.contributor.author Firnhaber, Cynthia
dc.contributor.author Foulkes, Andrea S.
dc.contributor.author Yin, Xiangfan
dc.contributor.author Glencross, Deborah
dc.contributor.author Gross, Robert
dc.contributor.author Kaplan, Mitch D.
dc.contributor.author Papasavvas, Emmanouil
dc.contributor.author Schulze, Doreen
dc.contributor.author Stevens, Wendy
dc.contributor.author Van der Merwe, M.T.
dc.contributor.author Waisberg, Rita
dc.contributor.author Sanne, Ian
dc.contributor.author Montaner, Luis J.
dc.date.accessioned 2010-11-19T13:28:11Z
dc.date.available 2010-11-19T13:28:11Z
dc.date.issued 2010-09
dc.description.abstract BACKGROUND: Advanced HIV infection can result in lipoatrophy and wasting, even in the absence of ongoing opportunistic infections, suggesting that HIV may directly affect adipose tissue amount and distribution. METHODS: We assessed the relationship of fat (measured using anthropometry, DEXA, MRI scans) or markers related to glucose and lipid metabolism with viral load in a cross-sectional sample of 83 antiretroviral-naïve HIV-1-infected South African women. A multivariable linear model was fitted to log10VL to assess the combined effect of these variables. RESULTS: In addition to higher T cell activation, women with viral load greater than the population median had lower waist circumference, body mass index and subcutaneous abdominal fat, as well as lower serum leptin. We demonstrate that leptin serum levels are inversely associated with viral replication, independent of the amount of adipose tissue. This association is maintained after adjusting for multiple variables associated with disease progression (i.e., cellular activation and innate immunity effector levels). CONCLUSIONS: Our results demonstrate that serum leptin levels are inversely associated with viral replication, independent of disease progression: we Postulate that leptin may affect viral replication. en_US
dc.identifier.citation Azzoni, L, Crowther, NJ, Firnhaber, C, Foulkes, AS, Yin, X, Glencross, D, Gross, R, Kaplan, MD, Papsavvas, E, Schulze, E, Stevens, W, Van Der Merwe, T, Waisberg, R, Sanne, I & Montaner, LJ 2010, 'Association between HIV replication and serum leptin levels : an observational study of a cohort of HIV-1-infected South African women', Journal of the International AIDS Society, vol. 13, no. 33, pp. 1-8. [http://www.jiasociety.org/] en_US
dc.identifier.issn 1758-2652
dc.identifier.other 10.1186/1758-2652-13-33
dc.identifier.uri http://hdl.handle.net/2263/15332
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights © 2010 Azzoni et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.subject HIV replication en_US
dc.subject Serum leptin levels en_US
dc.title Association between HIV replication and serum leptin levels : an observational study of a cohort of HIV-1-infected South African women en_US
dc.type Article en_US


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