Near-fatal outcome after administration of hyoscine-N-butylbromide (Buscopan®)

Show simple item record Milner, A. 2010-10-27T13:58:45Z 2010-10-27T13:58:45Z 2010-08
dc.description.abstract While undergoing conscious sedation for a gastroscopy, an 18-year-old female developed severe hypotension and loss of consciousness. This occurred shortly after an intravenous dose of hyoscine-N-butylbromide (Buscopan®). Resuscitation was performed over a period of 10 minutes and was successful. Once conscious, the patient complained of severe lower abdominal pain. Except for a signi cant metabolic acidosis (BE = -10), initial investigations were negative. She was transferred to the Intensive Care Unit (ICU) where the abdominal pain continued and the urine output was scanty for the rst 12 hours. Investigations were done to exclude: anaphylaxis, mesenteric ischaemia, angioneurotic oedema, pregnancy, porphyria, autoimmune disease and myocardial ischaemia. Finally it was postulated that the drug had either caused an anaphylactoid reaction or grossly augmented cardiovagal nervous inhibition. This resulted in hypotension which caused mesenteric ischaemia that in turn resulted in severe abdominal pain and a degree of renal shutdown. en_US
dc.identifier.citation Milner, A 2010, 'Near-fatal outcome after administration of hyoscine-N-butylbromide (Buscopan®)', Southern African Journal of Anaesthesia and Analgesia, vol. 16, no. 4, pp. 38-41. [] en_US
dc.identifier.issn 1027-9148
dc.language.iso en en_US
dc.publisher OpenJournals Publishing en_US
dc.rights This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.5 South Africa License. en_US
dc.subject Anaphylaxis en_US
dc.subject Angioneurotic oedema en_US
dc.subject Hyoscine-N-butylbromide en_US
dc.subject Porphyria en_US
dc.title Near-fatal outcome after administration of hyoscine-N-butylbromide (Buscopan®) en_US
dc.type Article en_US

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