Potassium uptake systems of Mycobacterium tuberculosis : genomic and protein organisation and potential roles in microbial pathogenesis and chemotherapy

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dc.contributor.author Cholo, Moloko C.
dc.contributor.author Van Rensburg, Elizabeth J.
dc.contributor.author Anderson, Ronald
dc.date.accessioned 2010-07-02T06:25:16Z
dc.date.available 2010-07-02T06:25:16Z
dc.date.issued 2008
dc.description.abstract Mycobacterium tuberculosis (MTB) is a formidable microbial pathogen which uses multiple mechanisms to subvert host immune defences. These include the effective, protective barrier presented by the outer waxy coat, intracellular concealment from host defences, and the ability to enter a prolonged, dormant phase in the infected host. Priority strategies to combat the scourge of TB include the identification of novel and selective targets on/in MTB which are amenable to pharmacological or immune-mediated control. Because they are structurally different from their counterparts in eukaryotic cells and are likely to be essential for survival and growth, the major K+ transporters of MTB represent alternative and novel targets for drug and vaccine design. These K+-uptake systems of MTB are the primary focus of this review, with particular emphasis on their genomic and protein structures, properties and functions, and potential roles in intracellular survival. en
dc.identifier.citation Cholo, MC, Van Rensburg, EJ & Anderson, R 2008, 'Potassium uptake systems of Mycobacterium tuberculosis : genomic and protein organisation and potential roles in microbial pathogenesis and chemotherapy', Southern African Journal of Epidemiology & Infection, vol. 23, no. 4, pp. 13-16. [http://www.sajei.co.za/index.php/SAJEI] en
dc.identifier.issn 10158782
dc.identifier.uri http://hdl.handle.net/2263/14389
dc.language.iso en en_US
dc.publisher Federation of Infectious Diseases Societies of South Africa en_US
dc.rights Federation of Infectious Diseases Societies of South Africa en_US
dc.subject.lcsh Mycobacterium tuberculosis en
dc.subject.lcsh Potassium en
dc.subject.lcsh Chemotherapy en
dc.subject.lcsh Genomics en
dc.subject.lcsh Pathogenic microorganisms en
dc.title Potassium uptake systems of Mycobacterium tuberculosis : genomic and protein organisation and potential roles in microbial pathogenesis and chemotherapy en
dc.type Article en


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