Pediatric disease burden and vaccination recommendations : understanding local differences

Show simple item record Gentile, Angela Bhutta, Zulfiqar Bravo, Lulu Samy, Aly Gamal Garcia, R. Dennis J. Hoosen, Anwar Ahmed Islam, Tazul Karimi, Abdollah Salem, Mona Simasathien, Sriluck Sohail, Amir Watanaveeradej, Veerachai Wiedenmayer, Karin Schmitt, Heinz-J. 2010-06-04T11:45:56Z 2010-06-04T11:45:56Z 2010
dc.description.abstract BACKGROUND: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. METHODS: This unique review highlights geographic differences in disease burden across certain countries in the African, Americas, Mediterranean, South-East Asian, and Western Pacific World Health Organization (WHO) regions, and relates this to vaccination coverage and local vaccine recommendations using the authors’ countries as illustrations. RESULTS: Substantial differences were observed in the incidence of these diseases and in vaccination coverage between the countries studied. Disease incidence often reflected inadequate surveillance, but also variable or poor vaccination coverage. Vaccination coverage against HepB was particularly low in the African and South-East Asian WHO regions; vaccination coverage against invasive Hib disease was low in these regions and in the Eastern Mediterranean and Western Pacific WHO regions. Vaccination schedules within some countries in these regions do not include, or have only recently included, vaccinations against HepB and Hib disease. The use of DTwP–HepB–Hib (diphtheria, tetanus, whole-cell pertussis, HepB, Hib) combination vaccines has now been adopted by some countries to help increase vaccination coverage. CONCLUSIONS: Vaccination coverage and vaccination schedules vary markedly between the countries studied, often according to the resources available. DTwP–HepB–Hib combination vaccines represent a cost-effective option, with the potential to substantially reduce the burden associated with these diseases by increasing coverage and compliance. en_US
dc.identifier.citation Gentile A, et al. Pediatric disease burden and vaccination recommendations: understanding local differences. Int J Infect Dis (2010), doi:10.1016/j.ijid.2009.11.006 en_US
dc.identifier.issn 1201-9712
dc.identifier.other 10.1016/j.ijid.2009.11.006
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights Elsevier en_US
dc.subject Pertussis en_US
dc.subject Diphtheria en_US
dc.subject Tetanus en_US
dc.subject Hepatitis B en_US
dc.subject Haemophilus influenzae type b en_US
dc.subject Measles en_US
dc.title Pediatric disease burden and vaccination recommendations : understanding local differences en_US
dc.type Postprint Article en_US

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