Four enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with α-, β-, 2-hydroxyl-3-trimethylammoniopropyl-β-(as chloride salt) and γ-cyclodextrins (γ-CDs) are proposed for the assay of L-histidine (L-his). The proposed electrodes showed near-Nernstian response over L-his but not over D-histidine (D-his). The recovery of L-his in the presence of D-his was higher than 99.10% with R.S.D. lower
than 0.1%. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.