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dc.contributor.author | De Jager, Christiaan | |
dc.contributor.author | Aneck-Hahn, Natalie Hildegard | |
dc.contributor.author | Bornman, Maria S. (Riana) | |
dc.contributor.author | Farias, Paulina | |
dc.contributor.author | Leter, G. | |
dc.contributor.author | Eleuteri, P. | |
dc.contributor.author | Rescia, M. | |
dc.contributor.author | Spanò, M. | |
dc.date.accessioned | 2010-04-13T06:17:28Z | |
dc.date.available | 2010-04-13T06:17:28Z | |
dc.date.issued | 2009-07 | |
dc.description.abstract | There is mounting evidence that deteriorated semen quality may be associated with increased serum concentration of 1,1,1-trichloro-2,2-bis(chlorodiphenyl)ethane (DDT) and its metabolites. The problem is exacerbated in situations where DDT is the only resource available to control malaria mosquitoes and DDT metabolite plasma concentration can reach 1000-fold the level found in other populations. There are limited and contradictory epidemiological data on whether DDT/dichlorodiphenyl-dichloroethylene (DDE) can also damage sperm DNA. Therefore, there is a need to investigate the possible adverse effects on human sperm genetic integrity in a sufficiently large study population with adequate exposure contrasts, especially in the high exposure range. | en |
dc.identifier.citation | De Jager, C, Aneck-Hahn, NH, Bornman, MS, Farias, P, Leter, G, Eleuteri, P, Rescia, M, & Spano, M 2009, ‘Sperm chromatin integrity in DDT-exposed young men living in a malaria area in the Limpopo Province, South Africa’, Human Reproduction, vol. 24, no.10, pp. 2429-2438. [http://humrep.oxfordjournals.org/] | en |
dc.identifier.issn | 0268-1161 | |
dc.identifier.other | 10.1093/humrep/dep249 | |
dc.identifier.uri | http://hdl.handle.net/2263/13876 | |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.rights | Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Reproduction following peer review. The definitive publisher-authenticated version of Human Reproduction, 2009, vol. 24, no. 10, pp. 2429-2438; doi:10.1093/humrep/dep249 is available online at: http://humrep.oxfordjournals.org/ | en |
dc.subject.lcsh | DNA damage -- South Africa -- Limpopo | en |
dc.subject.lcsh | Spermatozoa | en |
dc.subject.lcsh | Chromatin | en |
dc.subject.lcsh | DDT (Insecticide) -- Physiological effect -- South Africa -- Limpopo | en |
dc.subject.lcsh | Young men -- South Africa -- Limpopo | en |
dc.subject.lcsh | Malariotherapy -- South Africa -- Limpopo | en |
dc.title | Sperm chromatin integrity in DDT-exposed young men living in a malaria area in the Limpopo Province, South Africa | en |
dc.type | Article | en |