Lagos bat virus (LBV) constitutes genotype (gt) 2 in the Lyssavirus genus. In contrast to the gt1
lyssavirus, rabies virus (RABV), LBV was reported to have markedly reduced levels of peripheral
pathogenicity. However, this opinion was based on a study of one isolate of LBV only and the
reduction in pathogenicity was essentially attributed to the amino-acid substitution at position 333 of glycoprotein ectodomain. In the present study we have demonstrated that peripheral
pathogenicity of representatives of LBV in a murine model is as high as that of RABV.
Comparison of amino-acid substitutions among the viral glycoproteins, demonstrated significant
differences within two antigenic sites between different phylogenetic lineages of LBV. Such
molecular variability potentially contributes to differences in peripheral pathogenicity of