In this paper, we present seasonal and nocturnal variations of mesospheric sodium (Na) layer parameters observed over Gadanki (13.5° N, 79.2° E), based on 166 nights during the period from January 2005 to December 2006, for the first time. The total Na content decreases during the evening and reaches a minimum value around midnight and maximum in the early morning. The year-to-year variations illustrate that Na layers reach the peak value close to 93.5 km for the year 2005 and ~93 km for the year 2006 and falls to near zero value around 110 km. Though, seasonal variation of sodium density illustrate maximum values in September, December and March, we require a larger data base for September months to conclude the statement. The column abundance shows maximum during autumn equinox and minimum during winter. The obtained seasonal and nocturnal variation of sodium layer parameters are compared with mid-latitude observations and further possible mechanisms are discussed.