The loss of virulency of horsesickness virus in practice
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Date
Authors
Theiler, Arnold, Sir, 1867-1936
Journal Title
Journal ISSN
Volume Title
Publisher
Pretoria: Government Printer and Stationery Office
Abstract
Resume:
The experiments prove that a virus may become inert in practice; this avirulency is due to some foreign matter, inasmuch as inert virus added to virulent sterile virus promptly produces avirulency. It is probable that this avirulency is due to the presence of some germ, but the experiments have not been carried out to the extent necessary to determine the nature of this micro-organism.
Conclusions:
1. The avirulency of a virus takes place a certain time after mixing sterile to inert virus.
2. The avirulency takes place more rapidly when the mixture is kept in the incubator than when it is kept at room temperature.
3. The mixture of virulent and inert virus produces different results in injected animals according' 1"0 the method of inoculation. The same virus which proves inert after a subcutaneous injection may be virulent for an intrajugular injection.
4. The intrajugular injection of large doses of inert virus does not produce immunity.
5. It is clear that a certain virus may become inert, and therefore this fact influences the preparation and preservation of virus to be used in practice.
Description
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Keywords
Veterinary medicine, Veterinary reports, South Africa, Viral diseases, Inoculation experiments, Tzaneen virus, Temperature
Sustainable Development Goals
Citation
Theiler, A 1909, 'The loss of virulency of horse-sickness virus in practice', Report of the Government Veterinary Bacteriologist for the year 1907-1908, pp. 50-57.