Immunisation of mules with inadequate and adequate serum and virus, and the immunity obtained therefrom

Show simple item record Theiler, Arnold, Sir, 1867-1936
dc.contributor.editor Transvaal Department of Agriculture 2009-11-25T07:06:02Z 2009-11-25T07:06:02Z 1908
dc.description The journals have been scanned with a SupraScan 10000RGB scanner; 24-bit true colour, 400 dpi, saved in TIFF-format. Copies of the master images have been converted to Black & White, 1-bitmap images and OCRed with ABBYY Fine Reader v.9 software. Adobe Acrobat v.9 was used for the merging and conversion to the final presentation PDF-format. en
dc.description.abstract Conclusions: l. The simultaneous injection of serum 0 and adequate virus resulted in typical horse-sickness reactions, and the immunity obtained therefrom prevented a reaction when the adequate virus is subsequently injected. 2. The immunity obtained by a reaction after injection of serum O and virus 0 (adequate serum and virus) does not prevent a reaction due to a subsequent inoculation of virus of a different strain (Tzaneen and Bulawayo). 3. The simultaneous injection of serum 0 and virus Tzaneen (inadequate serum) is succeeded hy reactions which proved not to be more fatal to animals than that due to virus 0 (adequate serum). 4. The immunity obtained by this reaction was in no way complete. It did not prevent a reaction either due to a subsequent inoculation of a different strain (0 or Bulawayo), nor did it prevent reactions when the same strain of Tzaneen virus of a later generation was utilised. 5. The fact that a reaction was noted due to the subsequent inoculation of virus in an animal immunised with the same strain of virus can he explained either by accepting that the test virus, being of a higher generation and derived from horses, is of a greater virulency, or that the virus Tzaneen is already of a complex nature containing certain constituents of the 0 virus which are deviated by the 0 serum and accordingly during the immunisation leave no impression on the system of the animal. A subsequent inoculation of the same strain would then not meet the corresponding antibodies and a reaction would result. 6. In some of the animals a single injection of virus, together with adequate or nadequate serum, produced complete immunity against subsequent inoculations, hence a factor jn the animal has also something to do with the creation of immunity. 7. In the foregoing experiments it has been noted that a virus can attenuate and completely lose its virulency. 8. Virus T of the 12th generation has increased enormously in virulency, which shows itself in the immunisation and in the tests. en
dc.description.sponsorship The Equine Research Centre, Faculty of Veterinary Science, University of Pretoria gave financial support to this digitisation project. en
dc.format.extent This report consists of 31 pages. Complete descriptions of all the experiments are included. The analysis of the results are included as well as tabulated resumes of the experiments. en
dc.identifier.citation Theiler, A 1908, 'Immunisation of mules with inadequate and adequate serum and virus, and the immunity obtained therefrom', Report of the Government Veterinary Bacteriologist for the year 1906-1907, pp. 162-192. en
dc.language.iso en en
dc.publisher Pretoria: Government Printing and Stationery Office en
dc.rights © Transvaal Dept. of Agriculture (original). © University of Pretoria. Dept. of Library Services (digital). en
dc.subject Veterinary medicine en
dc.subject Veterinary bacteriology en
dc.subject Veterinary reports en
dc.subject South Africa en
dc.subject Inoculation experiments en
dc.subject Horse sickness en
dc.subject.lcsh Veterinary medicine -- History -- South Africa en
dc.subject.lcsh Veterinary medicine -- South Africa en
dc.subject.lcsh Veterinary vaccines -- South Africa en
dc.title Immunisation of mules with inadequate and adequate serum and virus, and the immunity obtained therefrom en
dc.type Technical Report en

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