Lineage 2 West Nile virus as cause of fatal neurologic disease in horses, South Africa

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dc.contributor.author Venter, Marietjie
dc.contributor.author Human, Stacey
dc.contributor.author Zaayman, Dewald
dc.contributor.author Gerdes, Gertruida Hermanna
dc.contributor.author Williams, J.H. (June Heather)
dc.contributor.author Steyl, Johan Christian Abraham
dc.contributor.author Leman, Patricia A.
dc.contributor.author Paweska, Janusz Tadeusz
dc.contributor.author Setzkorn, Hildegard
dc.contributor.author Rous, Gavin
dc.contributor.author Murray, Sue
dc.contributor.author Parker, Rissa
dc.contributor.author Donnellan, C.M.B. (Cynthia Mary Bridget)
dc.contributor.author Swanepoel, Robert
dc.date.accessioned 2009-09-10T09:16:43Z
dc.date.available 2009-09-10T09:16:43Z
dc.date.issued 2009-05-06
dc.description.abstract Serologic evidence suggests that West Nile virus (WNV) is widely distributed in horses in Southern Africa. However, because few neurologic cases have been reported, endemic lineage 2 strains were postulated to be non-pathogenic in horses. Recent evidence suggests that highly neuroinvasive lineage 2 strains exist in humans and mice. To determine whether neurologic cases are being missed in Southern Africa, we tested 80 serum or brain specimens from horses with unexplained fever (n = 48) and/or neurologic signs (n = 32) for WNV. From March 2007 through June 2008, using reverse transcription-PCR (RT-PCR) and immunoglobulin (Ig) M ELISA, we found WNV RNA or IgM in 7/32 horses with acute neurologic disease; 5 horses died or were euthanized. In 5/7 horses, no other pathogen was detected. DNA sequencing for all 5 RT-PCR-positive cases showed the virus belonged to lineage 2. WNV lineage 2 may cause neurologic disease in horses in southern Africa en_US
dc.description.sponsorship This study was funded by the National Research Foundation of South Africa. en_US
dc.identifier.citation Venter, M, Human, S, Zaayman, D, Gerdes, GH, Williams, J, Steyl, J, Leman, PA, Paweska, JT, Setzkorn, H, Rous, G, Murray, S, Parker, R, Donnellan, C, Swanepoel, R 2009, 'Lineage 2 West Nile virus as cause of fatal neurologic disease in horses, South Africa', Emerging Infectious Diseases, vol. 15, no. 6, pp. 877-884. [www.cdc.gov/eid] en_US
dc.identifier.issn 1080-6059
dc.identifier.other 10.3201/eid1506.081515
dc.identifier.uri http://hdl.handle.net/2263/11203
dc.language.iso en en_US
dc.publisher Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention en_US
dc.rights Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention en_US
dc.subject West Nile virus (WNV) en_US
dc.subject Horse en_US
dc.subject Lineage 2 en_US
dc.subject Reverse transcription polymerase chain reaction (RT-PCR) en_US
dc.subject Neurologic disease en_US
dc.subject Southern Africa en_US
dc.title Lineage 2 West Nile virus as cause of fatal neurologic disease in horses, South Africa en_US
dc.type Article en_US


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