C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome

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dc.contributor.author Koster, Liza Sally
dc.contributor.author Van Schoor, Mirinda
dc.contributor.author Goddard, Amelia
dc.contributor.author Thompson, P.N. (Peter N.)
dc.contributor.author Matjila, P.T. (Paul Tshepo)
dc.contributor.author Kjelgaard-Hansen, Mads
dc.date.accessioned 2009-08-06T06:37:39Z
dc.date.available 2009-08-06T06:37:39Z
dc.date.issued 2009-06
dc.description.abstract C-reactive protein (CRP) is a positive major acute-phase protein in dogs and can be used as a predictive marker for risk of disease and to monitor the response to treatment. Increased concentrations in certain diseases are associated with poor outcome. This cross-sectional, observational study of 75 dogs naturally infected with Babesia rossi was designed to examine the relationship between outcome and CRP concentration at admission and the magnitude of CRP change 24 hours after admission. Diagnosis was confirmed by polymerase chain reaction (PCR) and reverse line blot. CRP concentrations were determined by an automated human CRP Turbidometric Immunoassay, previously validated for use in dogs. There was no significant difference in mean CRP concentration between survivors (n=57), 107.5 ± 49.5 mg/ℓ and non-survivors (n=11), 122.1 ± 64.6 mg/ℓ at admission and using the exact logistic regression, adjusting for age and sex, there was no association with outcome (P = 0.53). Multiple regression analysis failed to show a significant relationship between admission CRP concentration and number of days of hospitalisation in the survivors, adjusting for age and sex (P=0.65). Similarly, no significance was found in the relationship between the magnitude of change in CRP concentration 24 hours after admission, and the number of days of hospitalisation in survivors, (P=0.34). It is concluded that CRP concentration, as a measure of the acute phase response, is not associated with outcome in canine babesiosis, and inflammation is unlikely to be the only cause of severity of disease. en
dc.identifier.citation Koster, S, Van Schoor, M, Goddard, A, Thompson, PN, Matjila, PT & Kjelgaard-Hansen, M 2009, 'C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome', Journal of the South African Veterinary Association, vol. 80, no. 2, pp. 87-91. [http://www.journals.co.za/ej/ejour_savet.html] en
dc.identifier.issn 0038-2809
dc.identifier.other 7403220452
dc.identifier.other J-2534-2013
dc.identifier.uri http://hdl.handle.net/2263/10929
dc.language.iso en en
dc.publisher South African Veterinary Association en
dc.rights South African Veterinary Association en
dc.subject Babesia rossi en
dc.subject C-reactive protein en
dc.subject Prognosis
dc.subject.lcsh Babesiosis -- South Africa en
dc.subject.lcsh Tick-borne diseases in animals en
dc.title C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome en
dc.type Article en


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