Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy

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dc.contributor.author Richter, Karin Louise
dc.contributor.author Janse van Rensburg, Estrelita
dc.contributor.author Van Heerden, Willem Francois Petrus
dc.contributor.author Boy, Sonja Catharina
dc.date.accessioned 2009-05-28T06:38:53Z
dc.date.available 2009-05-28T06:38:53Z
dc.date.issued 2008
dc.description.abstract BACKGROUND: To evaluate the prevalence of human papilloma virus (HPV) infection and types in the oral and cervix mucosa of treatment-naïve HIV-1-positive women with CD4 counts less than 300 cells per ml with no HPV-associated oral lesions. METHODS: Oral epithelium was harvested from the buccal mucosa and lateral borders of the tongue and cervical samples were collected from the endocervical area of 30 women, 22–64 years old. Cytobrush Plus cell collectors were used for sampling both anatomical areas. Genital pathology, obstetric and gynaecological history, co-morbid disease, hormone therapy, sexual behavior and smoking history were assessed via physical examination and clinical interviews. Special investigations included cervical Papanicolau smears, CD4 counts and HIV-1 viral loads. The linear array HPV test was used to determine HPV genotypes present in the specimens. RESULTS: Oral HPV were identified in 20% (n = 6) of the patients, of which two had infection with two HPV types. Genital HPV was found in 96.7% (n = 29) of the women, of which only 14 had cytological abnormalities on Papanicolau smear. Infection with multiple HPV types were present in 93.1% (n = 27) of the patients, with an average of four HPV types per individual. CONCLUSIONS: South African HIV-positive women with CD4 counts less than 300 cells per ml have a significant risk of cervical HPV strains and multiple strain infection of the cervix. The prevalence of HPV in normal oral mucosa was low but high-risk types were present. Limited correlation between oral HPV types and those identified in the cervical mucosa was found. en_US
dc.description.sponsorship National Health Laboratory Service of South Africa en_US
dc.identifier.citation Richter, KL, Janse van Rensburg, E, Van Heerden, WFP & Boy, SC 2008, 'Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy', Journal of Oral Pathology and Medicine, vol. 37, no. 9, pp. 555-559. [http://www3.interscience.wiley.com/journal/118487901/home] en_US
dc.identifier.issn 0904-2512
dc.identifier.other 10.1111/j.1600-0714.2008.00670.x
dc.identifier.uri http://hdl.handle.net/2263/10222
dc.language.iso en en_US
dc.publisher Wiley-Blackwell en_US
dc.rights Wiley-Blackwell. This is a preprint of an article published in Journal of Oral Pathology and Medicine [http://www.interscience.wiley.com] en_US
dc.subject Cervix en_US
dc.subject HIV en_US
dc.subject HPV strains en_US
dc.subject Oral mucosa en_US
dc.subject.lcsh HIV-positive women -- South Africa
dc.subject.lcsh HIV infections -- Research -- South Africa
dc.title Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy en_US
dc.type Postprint Article en_US


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