Browsing by Subject "S-adenosylmethionine decarboxylase"

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Functional consequences of the inhibition of Malaria S-adenosylmethionine decarboxylase as a key regulator of polyamine and methionine metabolism

Smit, Salome (University of Pretoria, 2010)

Malaria presents a global health risk that is becoming increasingly difficult to treat due to increased resistance of both the parasite and mosquito to all known drugs. Identification of novel drug targets are therefore ...
Structural and functional validation of S-adenosylmethionine decarboxylase as a novel drug target in the malaria parasite, Plasmodium falciparum

Coertzen, Dina (University of Pretoria, 2014)

Malaria is considered the most prevailing human parasitic disease. Despite various chemotherapeutic interventions being available, the parasite responsible for the most lethal form of malaria, Plasmodium falciparum, is ...
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli

Makhoba, Xolani Henry; Burger, Adelle; Coertzen, Dina; Zininga, Tawanda; Birkholtz, Lyn-Marie; Shonhai, Addmore (Public Library of Science, 2016-03-31)

S-adenosylmethionine decarboxylase (PfAdoMetDC) from Plasmodium falciparum is a prospective antimalarial drug target. The production of recombinant PfAdoMetDC for biochemical validation as a drug target is important. The ...

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