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Browsing by Author "Omar, Shaheed Vally"
Now showing items 1-20 of 44
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Omar, Shaheed Vally; Roth, Andreas; Ismail, Nazir Ahmed; Erasmus, Linda; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Paulse, Nuraan; Said, H.M. (Halima Mohammed); Hoosen, Anwar Ahmed; Reischl, Udo (Public Library of Science, 2011-09-22)BACKGROUND: The LightCyclerH Mycobacterium Detection Kit based on real-time PCR technology for the detection of Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii was recently developed. This study ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Moultrie, Harry; Bhyat, Zaheda; Conradie, Francesca; Enwerem, M.; Ferreira, Hannetjie; Hughes, Jennifer; Joseph, Lavania; Kock, Yulene; Letsaolo, Vancy; Maartens, Gary; Meintjes, Graeme; Ngcamu, Dumisani; Okozi, Nana; Padanilam, Xavier; Reuter, Anja; Romero, Rodolfo; Schaaf, Simon; Te Riele, Julian; Variava, Ebrahim; Van der Meulen, Minty; Ismail, Farzana; Ndjeka, Norbert (Elsevier, 2022-04)BACKGROUND : Bedaquiline improves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal ...
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Ismail, Nabila; Peters, Remco P.H.; Ismail, Nazir Ahmed; Omar, Shaheed Vally (American Society for Microbiology, 2019-03)Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline ...
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Ismail, Nabila; Omar, Shaheed Vally; Ismail, Nazir Ahmed; Peters, Remco P.H. (Elsevier, 2018-10)A comprehensive literature search was conducted to obtain previously published resistance associated mutations for bedaquiline, clofazimine and linezolid for Mycobacterium tuberculosis. Where possible, mutation frequencies ...
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Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (BioMed Central, 2012-12-22)BACKGROUND: The increasing problem of multi-drug-resistant (MDR) tuberculosis (TB) [ie resistant to at least isoniazid (INH) and rifampicin (RIF)] is becoming a global problem. Successful treatment outcome for MDR-TB depends ...
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Strydom, Kathy-Anne; Ismail, Farzana; Matabane, M.M.Z.; Onwuegbuna, O.; Omar, Shaheed Vally; Ismail, Nabila (American Society for Microbiology, 2015-09)In a head to head comparison of the MTBDRplus Version 2.0 (Hain Lifescience), Xpert® MTB/RIF (Cepheid) and the Anyplex™ MTB/NTM (Seegene) assays we demonstrate equal sensitivity (59/61; 96.7%) and specificity (53/54; ...
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Rukasha, Ivy; Said, Halima M.; Omar, Shaheed Vally; Koornhof, Hendrik; Dreyer, Andries W.; Musekiwa, Alfred; Moultrie, Harry; Hoosen, Anwar A.; Kaplan, Gilla; Fallows, Dorothy; Ismail, Nazir Ahmed (Frontiers Research Foundation, 2016-12-06)Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB ...
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Jha, Swati; Ismail, Nazir Ahmed; Clark, David; Lewis, James J.; Omar, Shaheed Vally; Dreyer, Andries; Chihota, Violet; Churchyard, Gavin; Dowdy, David W. (Public Library of Science, 2016-06-20)BACKGROUND Automated digital microscopy has the potential to improve the diagnosis of tuberculosis (TB), particularly in settings where molecular testing is too expensive to perform routinely. The cost-effectiveness of ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Joseph, Lavania; Govender, Netricia; Blows, Linsay; Ismail, Farzana; Koornhof, Hendrik; Dreyer, Andries W; Kaniga, Kone; Ndjeka, Norbert (Elsevier, 2018-02)BACKGROUND : Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB).We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess ...
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Said, Halima; Ratabane, John; Erasmus, Linda; Gardee, Yasmin; Omar, Shaheed Vally; Dreyer, Andries; Ismail, Farzana; Bhyat., Zaheda; Lebaka, Tiisetso; Van der Meulen, Minty; Gwala, Thabisile; Adelekan, Adeboye; Diallo, Karidia; Ismail, Nazir Ahmed (BMC, 2021-05)BACKGROUND: Studies have shown that drug-resistant tuberculosis (DR-TB) in South Africa (SA) is clonal and is caused mostly by transmission. Identifying transmission chains is important in controlling DR-TB. This study ...
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Ismail, Nazir Ahmed; Ismail, Farzana; Omar, Shaheed Vally; Blows, Linsay; Gardee, Yasmin; Koornhof, Hendrik; Onyebujoh, Philip C. (AOSIS Open Journals, 2018-12-06)BACKGROUND : The World Health Organization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. OBJECTIVE : We ...
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Ismail, Nazir Ahmed; Ismail, Farzana; Joseph, Lavania; Govender, Netricia; Blows, Linsay; Kaniga, Kone; Omar, Shaheed Vally (Nature Publishing Group, 2020-01-23)Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy. The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We defined interpretive criteria for ...
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Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (International Union Against Tuberculosis and Lung Disease, 2012-01)BACKGROUND: The GenoType® MTBDRsl assay (Hains, Lifesciences, Germany) is a new rapid assay for detection of resistance to second-line anti-tuberculosis drugs. METHOD: The MTBDRsl assay was evaluated on 342 MDR-TB isolates ...
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Gardee, Y.; Dreyer, A.W.; Koornhof, H.J.; Omar, Shaheed Vally; Da Silva, P.; Bhyat, Z.; Ismail, Nazir Ahmed (American Society for Microbiology, 2017-03)Early detection of resistance to second-line antituberculosis drugs is important for the management of multidrug-resistant tuberculosis (MDR-TB). The GenoType MTBDRsl version 2.0 (VER 2.0) line probe assay has been redesigned ...
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Omar, Shaheed Vally; Peters, Remco P.H.; Ismail, Nazir Ahmed; Jonkman, Kelly; Dreyer, Andries W.; Said, Halima M.; Gwalab, Thabisile; Ismail, Nabila; Fourie, P.B. (Petrus Bernardus) (Wiley, 2016-06)Molecular tests are revolutionizing diagnosis of tuberculosis (TB). Disease burden is concentrated in resource-poor countries with inadequate infrastructure and capacity resulting in delays for specimens to reach the ...
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Ferrian, Selena; Ross, Melinda; Conradie, Francesca; Omar, Shaheed Vally; Ismail, Nazir Ahmed; Little, Francesca; Kaplan, Gilla; allows, Dorothy F; Gray, Clive M. (Frontiers Media, 2018-10-25)Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to culture conversion (TCC) in patients with multidrug resistant tuberculosis (MDR-TB) would facilitate ...
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Zignol, Matteo; Cabibbe, Andrea Maurizio; Dean, Anna S.; Glaziou, Philippe; Alikhanova, Natavan; Ama, Cecilia; Andres, Sonke; Barbova, Anna; Borbe-Reyes, Angeli; Chin, Daniel P.; Cirillo, Daniela Maria; Colvin, Charlotte; Dadu, Andrei; Dreyer, Andries; Driesen, Michele; Gilpin, Christopher; Hasan, Rumina; Hasan, Zahra; Hoffner, Sven; Hussain, Alamdar; Ismail, Nazir Ahmed; Kamal, S.M. Mostofa; Khanzada, Faisal Masood; Kimerling, Michael; Kohl, Thomas Andreas; Mansjo, Mikael; Miotto, Paolo; Mukadi, Ya Diul; Mvusi, Lindiwe; Niemann, Stefan; Omar, Shaheed Vally; Rigouts, Leen; Schito, Marco; Sela, Ivita; Seyfaddinova, Mehriban; Skenders, Girts; Skrahina, Alena; Tahseen, Sabira; Wells, William A.; Zhurilo, Alexander; Weyer, Karin; Floyd, Katherine; Raviglione, Mario C. (Elsevier, 2018-06)BACKGROUND : In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Ismail, Nabila; Peters, Remco P.H. (Elsevier, 2018-10)Bedaquiline, clofazimine and linezolid are pertinent drugs for drug-resistant tuberculosis. Drug-resistant mutants provide insight into important resistance acquisition mechanisms. Methods for in vitro Mycobacterium ...
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Ismail, Nabila; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Peters, Remco P.H. (American Society for Microbiology, 2019-08)Bedaquiline resistance within Mycobacterium tuberculosis may arise through efflux-based (rv0678) or target-based (atpE) pathway mutations. M. tuberculosis mutant populations from each of five sequential steps in a passaging ...
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Omar, Shaheed Vally (University of Pretoria, 2015)The global control of tuberculosis (TB) is currently hindered by the low sensitivity of microscopy and the prolonged time-to-result of culture. Recent technical progress has improved both diagnostic accuracy and turnaround, ...
Now showing items 1-20 of 44