Browsing by Subject "N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles"

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Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria

Mayoka, Godfrey; Njoroge, Mathew; Okombo, John; Gibhard, Liezl; Sanches-Vaz, Margarida; Fontinha, Diana; Birkholtz, Lyn-Marie; Reader, Janette; Van der Watt, Mariette Elizabeth; Coetzer, Theresa L.; Lauterbach, Sonja B.; Churchyard, Alisje; Bezuidenhout, Belinda C.; Egan, Timothy J.; Yeates, Clive Leonard; Wittlin, Sergio; Prudêncio, Miguel; Chibale, Kelly (American Chemical Society, 2019)

Structure–activity relationship studies involving N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles (PBI) identified several compounds possessing potent in vitro activities against the asexual blood, liver, and gametocyte ...

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