Theron, Anne Elisabeth; Nolte, Elsie M.; Lafanechere, Laurence; Joubert, Annie M.(BioMed Central, 2013-08-27)
BACKGROUND: 2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic
cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism ...
Theron, Anne Elisabeth; Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Prudent, Renaud; Lafanechere, Laurence; Joubert, Annie M.(Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)
Using a novel synthesised sulphamoylated 2-methoxyestradiol
analogue, C19, two types of cell death, namely apoptosis and autophagy, were demonstrated
in vitro when cervical cancer HeLa cells were exposed to this compound.
Theron, Anne Elisabeth; Prudent, Renaud; Nolte, Elsie M.; Van den Bout, Jan Iman; Punchoo, Rivak; Marais, Sumari; Du Toit, Peet J.; Hlophe, Yvette; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Lafanechere, Laurence; Joubert, Annie M.(Springer, 2015-02)
PURPOSE : 2-Methoxyestradiol (2ME) is a promising anticancer
agent that disrupts the integrity and dynamics of the
spindle network. In order to overcome the pharmacokinetic
constraints of this compound, a panel of ...
2-Methoxyestradiol (2ME2) is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic
and antitumor properties. However, due to its limited biological accessibility, synthetic analogues ...