It can be concluded that compound-X induced both autophagy and apoptosis as a means of cell death in HeLa cells.

Using a novel synthesised sulphamoylated 2-methoxyestradiol analogue, C19, two types of cell death, namely apoptosis and autophagy, were demonstrated in vitro when cervical cancer HeLa cells were exposed to this compound.

2-Methoxyestradiol (2ME2) is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic and antitumor properties. However, due to its limited biological accessibility, synthetic analogues ...