Browsing by Author "Kumalo, Hezekiel M."

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1,4,7-Triazacyclononane restores the activity of β-lactam antibiotics against metallo-β-lactamase-producing Enterobacteriaceae : exploration of potential metallo-β-lactamase inhibitors

Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Kumalo, Hezekiel M.; Khan, René; Bester, Linda A.; Essack, Sabiha Y. (American Society for Microbiology, 2019-02)

Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors ...
In vitro potentiation of carbapenems with tannic acid against carbapenemase‐producing enterobacteriaceae : exploring natural products as potential carbapenemase inhibitors

Somboro, A.M.; Osei Sekyere, John; Amoako, Daniel G.; Kumalo, Hezekiel M.; Khan, R.; Bester, L.A.; Essack, S.Y. (Wiley, 2019-02)

AIMS : We hypothesized and confirmed that tannic acid (TA) reverses carbapenem resistance by inhibiting carbapenemases in class A and B carbapenemase‐producing Enterobacteriaceae. METHODS AND RESULTS: Minimum inhibitory ...

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