Browsing by Subject "JNK"

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Characterization of signalling pathways that link apoptosis and autophagy to cell death induced by estrone analogues which reversibly depolymerize microtubules

Mercier, Anne Elisabeth; Prudent, Renaud; Pepper, Michael Sean; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechere, Laurence; Joubert, Annie M. (MDPI, 2021-01-29)

The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15- tetraene-3-ol-17one (ESE-15-one) ...
Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways

Stander, Xiao Xing; Stander, Barend Andre; Joubert, Annie M. (Karger, 2015-04)

BACKGROUND : C9, a newly in silico-designed inhibitor of microtubule dynamics induces G2/M arrest culminating in apoptosis. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase, an enzyme that promotes pyruvate ...

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