Browsing by Author "Iqbal, Zamin"

Browsing by Author "Iqbal, Zamin"

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  • Drug-resistant tuberculosis in pet ring-tailed Lemur, Madagascar 
    LaFleur, Marni; Reuter, Kim E.; Hall, Michael B.; Rasoanaivo, Hoby H.; McKernan, Stuart; Ranaivomanana, Paulo; Michel, Anita Luise; Rabodoarivelo, Marie Sylvianne; Iqbal, Zamin; Rakotosamimanana, Niaina; Lapierre, Simon Grandjean (Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 2021-03)
    We diagnosed tuberculosis in an illegally wild-captured pet ring-tailed lemur manifesting lethargy, anorexia, and cervical lymphadenopathy. Whole-genome sequencing confirmed the Mycobacterium tuberculosis isolate belonged ...
  • Identifying lineage effects when controlling for population structure improves power in bacterial association studies 
    Earle, Sarah G.; Wu, Chieh-Hsi; Charlesworth, Jane; Stoesser, Nicole; Gordon, N. Claire; Walker, Timothy M.; Spencer, Chris C.A.; Iqbal, Zamin; Clifton, David A.; Hopkins, Katie L.; Woodford, Neil; Smith, E. Grace; Ismail, Nazir Ahmed; Llewelyn, Martin J.; Peto, Tim E.; Crook, Derrick W.; McVean, Gil; Walker, A. Sarah; Wilson, Daniel J. (Springer Nature, 2016-04-04)
    Bacteria pose unique challenges for genome-wide association studies because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome1,2. Although methods developed for human ...
  • Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis 
    Bradley, Phelim; Gordon, N. Claire; Walker, Timothy M.; Dunn, Laura; Heys, Simon; Huang, Bill; Earle, Sarah; Pankhurst, Louise J.; Anson, Luke; De Cesare, Mariateresa; Piazza, Paolo; Votintseva, Antonina A.; Golubchik, Tanya; Wilson, Daniel J.; Wyllie, David H.; Diel, Ronald; Niemann, Stefan; Feuerriegel, Silke; Kohl, Thomas A.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Smith, E. Grace; Buck, David; McVean, Gil; Walker, A. Sarah; Peto, Tim E.A.; Crook, Derrick W.; Iqbal, Zamin (Nature Publishing Group, 2015-12-21)
    The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of ...
  • Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance : a retrospective cohort study 
    Ismail, Nazir Ahmed; Omar, Shaheed Vally; Walker, Timothy M.; Kohl, Thomas A.; Hedge, Jessica; Elias, Carlos Del Ojo; Bradley, Phelim; Iqbal, Zamin; Feuerriegel, Silke; Niehaus, Katherine E.; Wilson, Daniel J.; Clifton, David A.; Kapatai, Georgia; Ip, Camilla L.C.; Bowden, Rory; Drobniewski, Francis A.; Allix-Béguec, Caroline; Gaudin, Cyril; Parkhill, Julian; Diel, Roland; Supply, Philip; Crook, Derrick W.; Smith, E. Grace; Walker, A. Sarah; Niemann, Stefan; Peto, Tim E. A.; Davies, J.; Crichton, C.; Acharya, M.; Madrid-Marquez, Eyre, D.; Wyllie, D.; Golubchik, T.; Munang, M. (Elsevier, 2015-10)
    BACKGROUND : Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drugsusceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistanced ...