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Browsing by Author "Durandt, Chrisna"
Now showing items 1-20 of 30
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Damerell, Victoria; Ambele, Melvin Anyasi; Salisbury, Shanel; Neumann-Mufweba, Alexis; Durandt, Chrisna; Pepper, Michael Sean; Prince, Sharon (Frontiers Media S.A., 2022-01-25)Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Dessels, Carla; Durandt, Chrisna; Pepper, Michael Sean (Taylor and Francis, 2019)Pooled human platelet lysate (pHPL) has been used to expand adipose-derived stromal cells (ASCs) and can be formulated using fresh or expired buffy coats (BCs) which are then resuspended in either plasma or an additive ...
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Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
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Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
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Nel, Sulette; Durandt, Chrisna; Murdoch, Candice; Pepper, Michael Sean (Elsevier, 2022-10)INTRODUCTION : The aim of this review is to provide a narrative review on the determinants of dental pulp stem cell (DPSC) heterogeneity that may affect the regenerative properties of these cells. METHODS : PubMed, Scopus, ...
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White, Marina; Feucht, Ute Dagmar; Duffley, Eleanor; Molokoane, Felicia; Durandt, Chrisna; Cassol, Edana; Rossouw, Theresa M.; Connor, Kristin L. (BMC, 2020-12-11)BACKGROUND : As mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a growing need to understand the development and health ...
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Durandt, Chrisna; Dessels, Carla; Da Silva, C.; Murdoch, Candice; Pepper, Michael Sean (Nature Publishing Group, 2019-11-04)Multipotent adipose-derived stromal/stem cells (ASCs) are candidates for use in cellular therapies for the treatment of a variety of conditions/diseases. Ex vivo expansion of freshly isolated ASCs may be necessary prior ...
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Ambele, Melvin Anyasi; Dessels, Carla; Durandt, Chrisna; Pepper, Michael Sean (Elsevier, 2016-05)We have undertaken an in-depth transcriptome analysis of adipogenesis in human adipose-derived stromal cells (ASCs) induced to differentiate into adipocytes in vitro. Gene expression was assessed on days 1, 7, 14 and ...
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Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
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Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
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Van Vollenstee, Fiona A.; Jackson, Carlo Stephan; Hoffmann, Danie; Potgieter, Marnie; Durandt, Chrisna; Pepper, Michael Sean (SpringerLink, 2016-10)Adipose derived mesenchymal stromal/stem cells (ASCs) are a heterogeneous population characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression of certain cell surface markers, while lacking ...
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Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
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Durandt, Chrisna (University of Pretoria, 2006-08-19)The full text of this thesis/dissertation is not available online. Please <a href="mailto:upetd@up.ac.za">contact us</a> if you need access. Read the abstract in the section 00front of this document.
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Mollentze, Jamie; Durandt, Chrisna; Pepper, Michael Sean (Hindawi Limited, 2021-09)The use of stem cells in regenerative medicine, including tissue engineering and transplantation, has generated a great deal of enthusiasm. Mesenchymal stromal/stem cells (MSCs) can be isolated from various tissues, most ...
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Dodgen, Tyren Mark; Hochfeld, Warren Ernst; Fickl, Heidi; Asfaha, Sahle M.; Durandt, Chrisna; Rheeder, Paul; Drögemoller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Labuschagne, Christiaan D.J.; Van Schalkwyk, Antoinette; Gaedigk, Andrea; Pepper, Michael Sean (BioMed Central, 2013-01-29)BACKGROUND: Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability in drug metabolism. Studies on ...
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Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
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Durandt, Chrisna; Van Vollenstee, Fiona A.; Dessels, Carla; Kallmeyer, Karlien; De Villiers, Danielle; Murdoch, Candice; Potgieter, Marnie; Pepper, Michael Sean (American Society for Biochemistry and Molecular Biology, 2016-04)The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One of the major challenges in studying adipogenesis is the lack of ...
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Durandt, Chrisna (University of Pretoria, 2010-08-30)Please read the abstract in the section 00front of this document
Now showing items 1-20 of 30