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Browsing by Supervisor "Cromarty, Allan Duncan"
Now showing items 1-20 of 57
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(University of Pretoria, 2018)Introduction: Diabetes mellitus is considered one of the four major non-communicable disease with the global prevalence of this disease nearly doubling over the past 40 years, making it one of the leading causes of morbidity ...
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(University of Pretoria, 2018)Numerous publications outlining the quantitative determination and semi-quantitative screening for both parent and metabolites of the natural plant derived cannabinoids have been reviewed due to the widespread use and abuse ...
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(University of Pretoria, 2013)Signal transducer and activator of transcription (STAT) is a family of intracellular proteins that are responsible for carrying the signal from the cell surface to the nucleus in response to specific ligands. Once in the ...
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(University of Pretoria, 2011-07-14)3-[3-(7-chloro-quinolin-4-yl amino) phenyl]-1-(4-methoxy-phenyl) prop-2-enone citrate “CITme” is a substituted quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate ...
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(University of Pretoria, 2020-07-31)Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality. It is particularly prevalent in people in sub-Saharan Africa, ...
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(University of Pretoria, 2019)Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical practice. Poor therapeutic response to medication ...
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(University of Pretoria, 2020-08)Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. ...
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(University of Pretoria, 2021)Pesticide poisoning is a global health concern with approximately three million cases being reported on an annual basis. The latter includes both intentional and unintentional poisonings. Organophosphorus and carbamate ...
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(University of Pretoria, 2018)Plasmodium falciparum is the causative agent of the most commonly fatal form of malaria in Africa with annual deaths of more than 300 000. The rapid development and spread of antimalarial drug resistance by the parasite ...
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(University of Pretoria, 2011-07-14)Bacterial infections remain a significant threat to human health. Due to the emergence of widespread antibiotic resistance, development of novel antibiotics is required in order to ensure that effective treatment remains ...
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(University of Pretoria, 2021-08)Cannabis contains numerous chemical compounds and has a multitude of therapeutic and pharmacological properties. The most-studied compounds in the cannabis plant are the cannabinoids, of which Δ⁹-tetrahydrocannabinol ...
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(University of Pretoria, 2013)Introduction: Chronic wounds are a great burden to care-givers and patients alike and are the main cause of many preventable amputations. Such wounds are treated with wound dressings but providing a wound environment that ...
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(University of Pretoria, 2022)Rationale: Attaining scientifically robust, clinically representative, and functionally translatable preclinical models for pharmaceutical research has become increasingly desirable. Relevant hepatic models are pivotal for ...
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(University of Pretoria, 2015)The most severe form of malaria in humans is caused by the intracellular parasite Plasmodium falciparum. The African continent bears the greatest burden of malaria with 90% of all malaria deaths occurring in sub-Saharan ...
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(University of Pretoria, 2017)Plasmodium falciparum is a protozoan parasite responsible for causing the most severe form of malaria in humans. This species is responsible for over 90% of malaria mortalities which occur predominantly in Africa. An ...
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(University of Pretoria, 2016)Malaria is a global pandemic that affects millions of people each year. It is a parasitic infection caused by the Plasmodium family, with Plasmodium falciparum being the most virulent strain. Malaria is transmitted to ...
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(University of Pretoria, 2010-09-16)Parkinson’s disease (PD) impairs the quality of life of patients and causes substantial social and economic burden. However the currently available symptomatic treatments, although initially effective, do not satisfactorily ...
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(University of Pretoria, 2018)Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor-alpha, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The lack of dependence on estrogen by TNBC cells makes ...
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(University of Pretoria, 2017)This dissertation describes the elucidation and implementation of derivatisation in the quantification of biologically active vitamin D metabolites in limited volume serum and dry blood spot samples (DBS) using the liquid ...
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(University of Pretoria, 2019)Introduction: Drugs have been removed from the market for years due to toxicity screening. The highest attrition from the market can be seen by drugs that cause hepatotoxicity. Most drugs are metabolised by phase I cytochrome ...
Now showing items 1-20 of 57