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Browsing by UP Author "Williams, Marni"
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Williams, Marni; Sprenger, Janina; Human, Esmare; Al-Karadaghic, Salem; Persson, Lo; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier B.V., 2011)Plasmodium falciparum like other organisms is dependent on polyamines for proliferation. Polyamine biosynthesis in these parasites is regulated by a unique bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase ...
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Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (BioMed Central, 2007-05)BACKGROUND: The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads and drug targets. Parasitespecific inserts in enzymes ...
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Clark, Katherine; Niemand, Jandeli; Reeksting, S.B. (Shaun Bernard); Smit, Salome; Van Brummelen, A.C. (Anna Catharina); Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Springer, 2010-02)Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections. However, when the classical polyamine ...
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Burger, Pieter Buys; Williams, Marni; Sprenger, Janina; Reeksting, S.B. (Shaun Bernard); Botha, M.E. (Mariette); Muller, Ingrid B.; Joubert, Fourie; Birkholtz, Lyn-Marie; Louw, Abraham Izak (BioMed Central, 2015-02-05)BACKGROUND : Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It’s resistance to most of the current drugs accentuates the pressing need for ...
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Birkholtz, Lyn-Marie; Williams, Marni; Niemand, Jandeli; Louw, Abraham Izak; Persson, Lo; Heby, Olle (Portland Press on behalf of the Biochemical Society, 2011-04-21)New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas’ disease, leishmaniasis and malaria. Enzymes in polyamine biosynthesis and thiol ...
Now showing items 1-5 of 5