- UPSpace Home
- →
- Browsing by UP Author
JavaScript is disabled for your browser. Some features of this site may not work without it.
Browsing by UP Author "Mabeta, Peaceful Lucy"
Now showing items 1-20 of 21
-
Mabeta, Peaceful Lucy; Pepper, Michael Sean (Elsevier, 2015-02)Herein, we describe the effects of Taxol on endothelioma cell growth and migration in vitro and on vascular tumor growth in vivo. The effects of Taxol on endothelioma cell growth were determined using the crystal violet ...
-
Ionescu, G.; Mabeta, Peaceful Lucy; Dippenaar, Nola; Muir, T.; Fourie, P.; Shelver, Graham (Health and Medical Publishing Group, 2008-07)No abstract available
-
Mabeta, Peaceful Lucy (Krakow Polish Physiological Society, 2013)Bleomycin is an antineoplastic drug that has recently been employed to treat haemangiomas, the most common vascular tumors of infancy, with very good results. To better understand the mechanism of bleomycin in ...
-
Mabeta, Peaceful Lucy; Pepper, Michael Sean (UBC Press, 2011-07)Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present ...
-
Forcados, Gilead Ebiegberi; James, Dorcas Bolanle; Scoltz, Wihan; Mabeta, Peaceful Lucy (Springer, 2021-06)Vitex doniana leaves are used in traditional medicine systems for the treatment of inflammatory-related disorders and breast cancer in West Africa. However, there is a dearth of scientific evidence on the effectiveness of ...
-
Mabeta, Peaceful Lucy; Pepper, Michael Sean (Springer, 2012-03)BACKGROUND: Hemangiomas are benign vascular tumors that are characterised by excessive angiogenesis. While there is no definitive treatment for these tumors, several angiogenesis inhibitors, including bleomycin, have ...
-
Mabeta, Peaceful Lucy (Elsevier, 2014-06)The phosphoinositide 3-kinase (PI3k) signaling pathway is involved in the regulation of numerous cellular activities. The pathway has also been implicated in the development of various tumors. In the context of vascular ...
-
Mabeta, Peaceful Lucy; Pavic, Kristina; Zorc, Branka (De Gruyter Open, 2018-09)In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide ...
-
Helena, Jolene Michelle; Joubert, Anna Margaretha; Mabeta, Peaceful Lucy; Coetzee, Magdalena; Lakier, Roy; Mercier, Anne Elisabeth (MDPI, 2021-08-17)2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is an in silico-designed estradiol analogue which has improved the parent compound’s efficacy in anti-cancer studies. In this proofof- concept study, the potential ...
-
Mabeta, Peaceful Lucy; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-01-15)Angiogenesis is one of the hallmarks of cancer, and the establishment of new blood vessels is vital to allow for a tumour to grow beyond 1–2 mm in size. The angiogenic switch is the term given to the point where the ...
-
Mabeta, Peaceful Lucy; Davis, P.F. (Health and Medical Publishing Group, 2008-07)Haemangiomas are neoplasms of the vasculature frequently encountered in paediatrics which, although benign, may present with serious complications. The potential beneficial effects of intralesional bleomycin injection (IBI) ...
-
Mphahlele, Malose J.; Khoza, Tebogo A.; Mabeta, Peaceful Lucy (MDPI Publishing, 2017)Herein we describe the synthesis and evaluation of a series of novel 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinazolin-1-ones for in vitro cytotoxicity against three human cancer cell lines as well as for potential antimalarial ...
-
Mphahlele, Malose Jack; Maluleka, Marole Maria; Makhafola, Tshepiso Jan; Mabeta, Peaceful Lucy (MDPI, 2014-11)Direct one-pot base-promoted conjugate addition–elimination of 6,8-dibromo-4- chloroquinoline-3-carbaldehyde with methyl mercaptoacetate and subsequent cyclization afforded methyl [(6,8-dibromothieno[3,2-c]quinoline)]- ...
-
Oncosuppressors and oncogenes : role in haemangioma genesis and potential for therapeutic targeting Mabeta, Peaceful Lucy (MDPI, 2018-04)Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. ...
-
Forcados, Gilead Ebiegberi; Mabeta, Peaceful Lucy; James, Dorcas Bolanle; Sallau, Abdullahi Balarabe; Muhammad, Aliyu (Taylor and Francis, 2017-04)Breast cancer remains a burden in both developed and developing countries, with higher mortality in developing countries. Attempts to eradicate cancer have not been successful despite the progress made in the development ...
-
Mabeta, Peaceful Lucy (Elsevier, 2020-07)Melanoma is the most aggressive form of skin cancer. Malignant melanoma in particular has a poor prognosis and although treatment has improved, drug resistance continues to be a challenge. Angiogenesis, the formation of ...
-
Mabeta, Peaceful Lucy (De Gruyter Open, 2016-09)PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells ...
-
Scholtz, Wihan; Mabeta, Peaceful Lucy (University of South Bohemia in České Budějovice, 2020-12-07)Sunitinib malate is a small molecule that targets multiple receptor tyrosine kinases and blocks their activity. Receptors targeted by sunitinib are implicated in tumor vascularization and are overexpressed by vascular ...
-
Mabeta, Peaceful Lucy; Dippenaar, Nola; Shelver, Graham (PharmSciDirect, 2012-10-13)Bleomycin is an anti-neoplastic drug that has recently been used for the treatment of vascular anomalies. The plasma concentration of bleomycin following intralesional injection into vascular lesions is unknown. An expedient ...
-
Mukorera, Varaidzo; Kirberger, Robert M.; Mabeta, Peaceful Lucy; Dvir, Eran (Wiley-Blackwell, 2013-11)BACKGROUND : Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor associated with tumor development.Spirocerca lupi is a nematode of canids that induces an esophageal nodule that progresses to a ...
Now showing items 1-20 of 21