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Browsing by UP Author "Jurgens, Tamarin"

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Comparative evaluation of the cytotoxicity of doxorubicin in BT-20 triple-negative breast carcinoma monolayer and spheroid cultures

Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)

Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
A novel non‑sulphamoylated 2‑methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

Botes, Mandie; Jurgens, Tamarin; Riahi, Zohreh; Visagie, M.H. (Michelle Helen); Janse van Vuuren, Rustelle; Joubert, Annie M.; Van den Bout, Jan Iman (BioMed Central, 2018-11-19)

BACKGROUND : 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. ...
Novel sulphamoylated 2‑methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

Janse van Vuuren, Rustelle; Botes, Mandie; Jurgens, Tamarin; Joubert, Annie M.; Van den Bout, Jan Iman (BioMed Central, 2019-01-03)

BACKGROUND : The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In ...

Browsing by UP Author "Jurgens, Tamarin"

Browsing by UP Author "Jurgens, Tamarin"

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