Browsing by UP Author "Human, Esmare"

Browsing by UP Author "Human, Esmare"

Sort by: Order: Results:

  • Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum 
    Williams, Marni; Sprenger, Janina; Human, Esmare; Al-Karadaghic, Salem; Persson, Lo; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier B.V., 2011)
    Plasmodium falciparum like other organisms is dependent on polyamines for proliferation. Polyamine biosynthesis in these parasites is regulated by a unique bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase ...
  • Heterologous expression or plasmodial proteins for structural studies and functional annotation 
    Birkholtz, Lyn-Marie; Blatch, Gregory; Coetzer, Theresa L.; Hoppe, Heinrich C.; Human, Esmare; Morris, Elizabeth J.; Ngcete, Zoleka; Oldfield, Lyndon; Roth, Robyn; Shonhai, Addmore; Stephens, Linda L.; Louw, Abraham Izak (BioMed Central, 2008)
    Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective chloroquine ...
  • Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine 
    Camara, Djeneb; Bisanz, Cordelia; Barette, Caroline; Van Daele, Jeroen; Human, Esmare; Barnard, Bernice; Van der Straeten, Dominique; Stove, Christophe P.; Lambert, Willy E.; Douce, Roland; Marechal, Eric; Birkholtz, Lyn-Marie; Cesbron-Delauw, Marie-France; Dumas, Renaud; Rebeille, Fabrice (American Society for Biochemistry and Molecular Biology, 2012-05)
    BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. ...