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Browsing by UP Author "Hull, Rodney"
Now showing items 1-20 of 38
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Dlamini, Zodwa; Skepu, Amanda; Kim, Namkug; Mkhabele, Mahlori; Khanyile, Richard; Molefi, Thulo; Mbatha, Sikhumbuzo; Setlai, Botle; Mulaudzi, Thanyani Victor; Mabongo, Mzubanzi; Bida, Nndweleni Meshack; Kgoebane-Maseko, Minah; Mathabe, Kgomotso; Lockhat, Zarina I.; Kgokolo, C.M.; Chauke-Malinga, Nkhensani; Ramagaga, Serwalo; Hull, Rodney (Elsevier, 2022)Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic ...
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Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen Bates; Dlamini, Zodwa (MDPI, 2023-08-07)Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
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Dlamini, Zodwa; Francies, Flavia Zita; Hull, Rodney; Marima, Rahaba (Elsevier, 2020)Artificial intelligence (AI) and machine learning have significantly influenced many facets of the healthcare sector. Advancement in technology has paved the way for analysis of big datasets in a cost- and time-effective ...
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Francies, Flavia Zita; Hull, Rodney; Khanyile, Richard; Dlamini, Zodwa (e-Century Publishing, 2020-05)Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have ...
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Marima, Rahaba; Hull, Rodney; Lolas, Georgios; Syrigos, Konstantinos N.; Kgoebane-Maseko, Minah; Kaufmann, Andreas Martin; Dlamini, Zodwa (MDPI Publishing, 2021-09-18)Cervical cancer is a public health problem and has devastating effects in low-to-middle income countries (LTMICs) such as the sub-Saharan African (SSA) countries. Infection by the human papillomavirus (HPV) is the main ...
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Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020)Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more common and accounts for 70% of all cases. In 2018 ...
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Hull, Rodney; Francies, Flavia Zita; Oyomno, Meryl; Dlamini, Zodwa (Dove Medical Press, 2020-10)Each year, colorectal cancers (CRCs) affect over a quarter of a million people. The risk of developing CRC in industrialized nations is approximately 5%. When the disease is localised, treatment success rates range from ...
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Basera, Afra; Hull, Rodney; Demetriou, Demetra Danielle; Bates, David O.; Kaufmann, Andreas Martin; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2022-09-16)Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer. However, numerous ...
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Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020-12)The Sub-Saharan countries, particularly South Africa has the largest number of people living with HIV, accompanied by the largest antiretroviral treatment (ART) programme in the world. The Highly Active Antiretroviral ...
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Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Frontiers Media, 2020-08)Highly active anti-retroviral treatment (HAART) is currently the most effective treatment for HIV/AIDS. Additionally, HIV positive patients receiving HAART have a better health-related quality of life (HRQoL). Cancers ...
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Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Impact Journals, 2020-10)The cell-cycle related genes are potential gene targets in understanding the effects of efavirenz (EFV) in lung cancer. The present study aimed at investigating the expression changes of cell-cycle related genes in ...
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Mbatha, Sikhumbuzo Z.; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-09-22)Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality ...
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Mbita, Zukile; Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Dlamini, Zodwa (Lippincott, Williams and Wilkins, 2019-09)Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been demonstrated to interact with two tumour suppressors, ...
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Dlamini, Zodwa; Alaouna, Mohammed; Mbatha, Sikhumbuzo Z.; Bhayat, Ahmed; Mabongo, Mzubanzi; Chatziioannou, Aristotelis; Hull, Rodney (MDPI, 2021-03-15)Head and neck cancers include cancers that originate from a variety of locations. These include the mouth, nasal cavity, throat, sinuses, and salivary glands. These cancers are the sixth most diagnosed cancers worldwide. ...
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Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
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Dlamini, Zodwa; Marima, Rahaba; Hull, Rodney; Syrigos, Konstantinos N.; Lolas, Georgios; Mphahlele, Lebogang; Mbita, Zukile (Elsevier, 2021-08-11)Worldwide, lung cancer is a leading cause of cancer-related deaths and is the most commonly diagnosed form of cancer. A major characteristic of lung cancer is its profound clinical, histological and molecular heterogeneity. This ...
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Francies, Flavia Zita; Marima, Rahaba; Hull, Rodney; Molefi, Thulo; Dlamini, Zodwa (e-Century Publishing, 2020-10)Endometrial cancer, also known as uterine cancer, is the most common gynaecological malignancy with burgeoning incidence and mortality rates globally. Racial disparity, socioeconomic and geographical differences are important ...
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Dlamini, Zodwa; Mbele, Mzwandile; Makhafola, Tshepiso J.; Hull, Rodney; Marima, Rahaba (MDPI Publishing, 2021-07-29)Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest number of HIV infections. Malignancies previously associated ...
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Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
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Dlamini, Zodwa; Alaouna, Mohammed; Cholo, Moloko C.; Hull, Rodney (Elsevier, 2020-09)Mycobacterium tuberculosis (Mtb), is one of the foremost organisms causing mortality in humans, and has been for most of human history. When faced with an infection the human immune system is ordinarily very competent in ...
Now showing items 1-20 of 38