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Browsing by UP Author "Cromarty, Allan Duncan"
Now showing items 1-20 of 29
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Koot, Dwayne Jonathan; Cromarty, Allan Duncan (Springer, 2015-06)Contemporary chemotherapy is limited by disseminated, resistant cancer. Targeting nanoparticulate drug delivery systems that encapsulate synergistic drug combinations are a rational means to increase the therapeutic ...
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Cordier, Werner; Gulumian, Mary; Cromarty, Allan Duncan; Steenkamp, Vanessa (BioMed Central, 2013-05-28)BACKGROUND: Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants. Exogenous supplementation with antioxidants could result in ...
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Jansen van Rensburg, Connie E.; Snyman, Jacques Rene; Mokoele, T.L.; Cromarty, Allan Duncan (Springer, 2007-10)OBJECTIVES:The effects of two humate products were compared to that of prednisolone on a contact hypersensitivity rat model. METHODS: Rats, sensitized with dinitrofluorobenzene (DNFB), were placed on a daily oral treatment ...
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Shelembe, Jeremiah Sijubo; Cromarty, Allan Duncan; Bester, Megan Jean; Minnaar, Amanda; Duodu, Kwaku Gyebi (Wiley-Blackwell, 2012-03)Freeze-dried aqueous phenolic extracts with possible application as natural antioxidant functional food ingredients were prepared from marama bean seed coats by extracting with water. Phenolic acids, flavonoids and ...
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Hurrell, Tracey; Ellero, Andrea Antonio; Masso, Zelie Flavienne; Cromarty, Allan Duncan (Elsevier, 2018-08)Hepatotoxicity remains a major challenge in drug development despite preclinical toxicity screening using hepatocytes of human origin. To overcome some limitations of reproducing the hepatic phenotype, more structurally ...
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Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
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Mothibeli, K.T.; Mercier, Anne Elisabeth; Cromarty, Allan Duncan; Rheeder, M.; Naidoo, Vinny; Olorunju, S.A.S.; Joubert, Anna Margaretha (Allied Academies, 2018)2-methoxyestradiol (2ME) is an endogenous 17β-oestradiol metabolite that exerts antiproliferative, antiangiogenic and antitumour activity on cancer cells both in vitro and in vivo. However, the use of 2ME as a potential ...
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Ellero, Andrea Antonio; Van den Bout, Iman; Vlok, Mare; Cromarty, Allan Duncan; Hurrell, Tracey (Nature Research, 2021-05)Three-dimensional models are considered a powerful tool for improving the concordance between in vitro and in vivo phenotypes. However, the duration of spheroid culture may infuence the degree of correlation between these ...
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Leuschner, Machel; Cromarty, Allan Duncan (MDPI, 2023-07-05)Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent metabolism and altered drug absorption via expressed transport channels such as P-glycoprotein (P-gp) contribute to the adverse ...
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Determination of salivary efavirenz by liquid chromatography coupled with tandem mass spectrometry Theron, Anri; Cromarty, Allan Duncan; Rheeders, Malie; Viljoen, Michelle (Elsevier, 2010-10)A novel and robust screening method for the determination of the non-nucleoside reverse transcriptase inhibitor, efavirenz (EFV), in human saliva has been developed and validated based on high performance liquid ...
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Mohamed, Khaled M.; Cromarty, Allan Duncan; Steenkamp, Vanessa (Elsevier, 2015-08)In some developing countries, p-phenylenediamine (PPD) is used in combination with Henna as hair dye or skin decoration. A sensitive LC–MS/MS method was developed and validated for the simultaneous determination of ...
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Shelembe, Jeremiah Sijubo; Cromarty, Allan Duncan; Bester, Megan Jean; Minnaar, Amanda; Duodu, Kwaku Gyebi (Wiley- Blackwell, 2014-02)The effect of extraction under acidic condition (pH 2) on phenolic compounds and antioxidant potential of aqueous extracts fromcondensed tannin sorghumbran was investigated. The protective effect of extracts prepared ...
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Pallant, C.A.; Cromarty, Allan Duncan; Steenkamp, Vanessa (Elsevier, 2012-02)Ethnopharmacological relevance: Bacterial infections remain a significant threat to human health. Due to the emergence of widespread antibiotic resistance, development of novel antibiotics is required in order to ensure ...
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Dzikiti, Tarisai Brighton; Stegmann, George F.; Cromarty, Allan Duncan; Dzikiti, Loveness Nyaradzo; Hellebrekers, Ludo J. (Wiley-Blackwell, 2011-01)OBJECTIVE: To evaluate the effects of propofol, on isoflurane minimum alveolar concentration (MAC) and cardiovascular function in mechanically ventilated goats. STUDY DESIGN: Prospective, randomized, crossover ...
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Cordier, Werner; Cromarty, Allan Duncan; Botha, Elsabie M.D.; Steenkamp, Vanessa (SAGE, 2012-03)The use of herbal preparations for staunching blood flow and reducing the risk of vascular thrombosis is common worldwide. In this study, aqueous and methanolic extracts of plants used to treat blood-associated complaints ...
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Dodgen, Tyren Mark; Drögemöller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Steffens, Francois E.; Cromarty, Allan Duncan; Alessandrini, Marco; Pepper, Michael Sean (Future Medicine, 2015-08)AIM : To align predicted and measured CYP2C19 phenotype in a South African cohort. MATERIALS AND METHODS : Genotyping of CYP2C19*2, *3, *9, *15, *17, *27 and *28 was performed using PCR-RFLP, and an Activity Score (AS) ...
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Van Tonder, Jacob John; Gulumian, Mary; Cromarty, Allan Duncan; Steenkamp, Vanessa (SAGE, 2014-01)The organochlorine pesticide, dichlorodiphenyltrichloroethane (DDT), is still used to combat the spread of malaria in several developing countries despite its accumulation and known hepatotoxic effects that have ...
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Van Tonder, Alet; Joubert, Annie M.; Cromarty, Allan Duncan (BioMed Central, 2013-02-20)BACKGROUND : The tetrazolium-based MTT assay has long been regarded as the gold standard of cytotoxicity assays as it is highly sensitive and has been miniaturised for use as a high-throughput screening assay. However, ...
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Greeff, Oppel Bernhardt Wilhelm; Van Tonder, Jacob John; Cromarty, Allan Duncan; Lowman, Warren; Becker, Piet J.; Nell, Margo Judith (MedPharm Publications, 2015)INTRODUCTION : Teicoplanin is an effective treatment option against methicillin-resistant, Gram-positive bacteria, like Staphylococcus aureus. It is a glycopeptide antibiotic, produced through microbial fermentation, a ...
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Naude, P.J.W. (Petrus Johan Wichardt); Cromarty, Allan Duncan; Jansen van Rensburg, Constance Elizabeth (Springer, 2010-02)It has been shown in a previous study that brown coal-derived potassium humate is safe and effective in suppressing contact hypersensitivity in rats. In this study the efficacy of potassium humate on other types of ...
Now showing items 1-20 of 29