Browsing by Subject "P-selectin"

Browsing by Subject "P-selectin"

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  • Clofazimine, but not isoniazid or rifampicin, augments platelet activation in vitro 
    Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)
    Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
  • Pneumolysin mediates platelet activation in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)
    This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...