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Browsing by Author "Ibrahim, Mohammed Auwal"
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Zakariah, Musa; Ibrahim, Mohammed Auwal; Molele, Reneilwe A.; McGaw, Lyndy Joy (Elsevier, 2020-12)It has been established that excess germ cells in normal and in pathological conditions are removed from testicular tissue by the mechanism of apoptosis. Studies on germ cell apoptosis in avian species are grossly lacking, ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Abdullahi, Aliyu Dantani; Aminu, Suleiman; Aliyu, Abubakar Babando; Musa, Aliyu Muhammad; Musa, Bashir; Bester, Megan; Gaspar, A.R.M. (Anabella Regina Marques) (Springer, 2023-04)The multifactorial nature of type 2 diabetes mellitus (T2DM) has driven a need to discover multifunctional antidiabetic peptides preferably from functional food sources for possible application as antidiabetic supplements. ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Gaspar, Anabella Regina Marques (Elsevier, 2020-10)Type 2 diabetes is a multifactorial disease and drugs with multifunctional properties are required. The peptide, SQSPA, was reported to be a potent and gastrointestinally stable α-glucosidase inhibitory peptide. In this ...
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Adeosun, Idowu Jesulayomi; Baloyi, Itumeleng Tsebang; Aljoundi, Aimen K.; Salifu, Elliasu Y.; Ibrahim, Mohammed Auwal; Cosa, Sekelwa (Taylor and Francis, 2023)Klebsiella pneumoniae is one of the perturbing multidrug resistant (MDR) and ESKAPE pathogens contributing to the mounting morbidity, mortality and extended rate of hospitalization. Its virulence, often regulated by quorum ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2019-02)Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2020-12)Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2018-11)Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as α-glucosidase and α-amylase. The present study was conducted to identify novel α-glucosidase inhibitory peptides ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2018-02)Bioactive peptides are emerging as promising class of drugs that could serve as α-glucosidase inhibitors for the treatment of type 2 diabetes. This article identifies structural and physicochemical requirements for the ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Bentham Science, 2019-07)BACKGROUND : Peptide-based therapeutics offer a unique avenue for the development of novel agents for the treatment of diabetes mellitus including α-glucosidase inhibitors. The peptide, SQSPA, was reported to possess to α ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2019-06)In silico analysis was used to evaluate storage proteins from plant tubers as potential precursors of bioactive peptides after simulated gastrointestinal digestion. Proteins derived from potato (patatins), sweet potato ...
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