Directions to overcome therapy resistance in cancer

Abstract

Novel modalities for treatment of cancer have emerged because of advances in technology that have enabled expansion of our understanding of how cells transform to become cancerous and the role of the tumor microenvironment (TME). However, resistance to therapy poses a major problem for the successful treatment of cancer. Ongoing collaborative efforts of clinicians and researchers from different parts of the world have also led to an emerging understanding of how cancer cells evolve to resist treatment. Jerry Madukwe, the Editor-in-Chief of Trends in Pharmacological Sciences asked experts in the field to reflect on the global challenges in the cancer field and provide their views on what they see as the most pressing questions and research directions to overcome therapy resistance in cancer.