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dc.contributor.author | Anderson, Motswedi![]() |
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dc.contributor.author | Phinius, Bonolo B.![]() |
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dc.contributor.author | Phakedi, Basetsana![]() |
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dc.contributor.author | Mudanga, Mbatshi![]() |
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dc.contributor.author | Bhebhe, Lynnette![]() |
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dc.contributor.author | Tlhabano, Girlie N.![]() |
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dc.contributor.author | Motshosi, Patience![]() |
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dc.contributor.author | Ratsoma, Tsholofelo![]() |
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dc.contributor.author | Baruti, Kabo![]() |
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dc.contributor.author | Mpebe, Gorata![]() |
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dc.contributor.author | Choga, Wonderful T.![]() |
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dc.contributor.author | Marlink, Richard![]() |
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dc.contributor.author | Glebe, Dieter![]() |
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dc.contributor.author | Blackard, Jason T.![]() |
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dc.contributor.author | Moyo, Sikhulile![]() |
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dc.contributor.author | Kramvis, Anna![]() |
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dc.contributor.author | Gaseitsiwe, Simani![]() |
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dc.date.accessioned | 2024-12-04T05:54:28Z | |
dc.date.available | 2024-12-04T05:54:28Z | |
dc.date.issued | 2024-05 | |
dc.description | DATA AVAILABITY STATEMENT: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. | en_US |
dc.description.abstract | AIM: This study aimed to determine the kinetics of occult hepatitis B virus infections (OBI) among people with HIV (PWH). METHODS: The study used archived plasma samples from longitudinal HIV natural history studies. We identified new OBI cases and assessed risk factors for OBI using Cox proportional hazards regression analysis. RESULTS: At baseline, 8 of 382 [(2.1%) (95% CI: 1.06–4.1)] samples tested positive for hepatitis B surface antigen (HBsAg+). Of the 374 HBsAg-negative samples, 76 had sufficient sample volume for HBV DNA screening. OBI positivity (OBI+) at baseline was reported in 11 of 76 [14.7 95% CI (8.3–24.1)] HBsAg-negative (HBsAg−) participants. Baseline HBsAg-negative samples with sufficient follow-up samples (n = 90) were used for analysis of newly identified OBI cases. Participants contributed 129.74 person-years to the study and were followed for a median of 1.02 years (IQR: 1.00–2.00). Cumulatively, there were 34 newly identified OBI cases from the 90 participants, at the rate of 26.2/100 person-years (95% CI: 18.7–36.7). Newly identified OBI cases were more common among men than women (61.1% vs. 31.9%) and among participants with CD4+ T-cell counts ≤450 cells/mL (p-value = 0.02). Most of the newly identified OBI cases [55.9% (19/34)] were possible reactivations as they were previously HBV core antibody positive. CONCLUSION: There was a high rate of newly identified OBI among young PWH in Botswana, especially in men and in participants with lower CD4+ T-cell counts. OBI screening in PWH should be considered because of the risk of transmission, possible reactivation, and risk factors for the development of chronic liver disease, including hepatocellular carcinoma. | en_US |
dc.description.department | School of Health Systems and Public Health (SHSPH) | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sdg | SDG-10:Reduces inequalities | en_US |
dc.description.sponsorship | The Wellcome grant and SANTHE, NIH Fogarty International Centre, Pan African Bioinformatics Network for the Human Heredity and Health in Africa, HHS/NIH/National Institute of Allergy and Infectious Diseases , National Institutes of Health Fogarty International Centre , the National Institutes of Health Common Fund, the Trials of Excellence in Southern Africa, the European Union, and the Bill and Melinda Gates grant. | en_US |
dc.description.uri | https://www.frontiersin.org/journals/microbiology | en_US |
dc.identifier.citation | Anderson, M., Phinius, B.B., Phakedi, B.K., Mudanga, M., Bhebhe, L.N., Tlhabano, G.N., Motshosi, P., Ratsoma, T., Baruti, K., Mpebe, G., Choga, W.T., Marlink, R., Glebe, D., Blackard, J.T., Moyo, S., Kramvis, A. & Gaseitsiwe, S. (2024) Persistence and risk factors of occult hepatitis B virus infections among antiretroviral therapy-naïve people living with HIV in Botswana. Frontiers in Microbiology 15:1342862. doi: 10.3389/fmicb.2024.1342862. | en_US |
dc.identifier.issn | 1664-302X (online) | |
dc.identifier.other | 10.3389/fmicb.2024.1342862 | |
dc.identifier.uri | http://hdl.handle.net/2263/99740 | |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | © 2024 Anderson, Phinius, Phakedi, Mudanga, Bhebhe, Tlhabano, Motshosi, Ratsoma, Baruti, Mpebe, Choga, Marlink, Glebe, Blackard, Moyo, Kramvis and Gaseitsiwe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). | en_US |
dc.subject | Incidence | en_US |
dc.subject | HIV/HBV | en_US |
dc.subject | Hepatitis B surface antigen (HBsAg) negative | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.subject | SDG-10: Reduced inequalities | en_US |
dc.subject | Hepatitis B virus (HBV) | en_US |
dc.subject | Occult hepatitis B (OBI) | en_US |
dc.subject | Human immunodeficiency virus (HIV) | en_US |
dc.subject | People living with HIV (PLHIV) | en_US |
dc.title | Persistence and risk factors of occult hepatitis B virus infections among antiretroviral therapy-naïve people living with HIV in Botswana | en_US |
dc.type | Article | en_US |