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dc.contributor.advisor | Vleggaar, Robert | |
dc.contributor.coadvisor | Modro, T.A. | |
dc.contributor.postgraduate | Marais, Stephanus Francois | |
dc.date.accessioned | 2024-11-27T09:16:30Z | |
dc.date.available | 2024-11-27T09:16:30Z | |
dc.date.created | 22/01/18 | |
dc.date.issued | 1990 | |
dc.description | Dissertation (MSc (Chemistry))--University of Pretoria, 1990. | |
dc.description.abstract | Investigation of toxic extracts from cultures of the fungus Diplodia maydis (Berk.) Sacc. [ synonyms D. zeae (Schw.) Lev. and Stenocarpella maydis (Berk.)] led to the isolation of diplodiatoxin, a known metabolite, as well as four new metabolites viz. 3-hydroxydiplodiatoxin stenocarpin, steno-carpin 6-0-(4-0-methyl-orsellinate) and carpellin. The structure elucidation of the new compounds is based on a detailed analysis of their highfield 1H and 13 c nuclear magnetic resonance spectra. The relative configurations were deduced from the magnitude of the proton-proton coupling constants and the results obtained from homonuclear proton-proton nuclear Overhauser effect (n.O.e.) studies. The absolute configuration of stenocarpin 6 - 0- ( 4 - 0-methylorsellina te) was determined by the 'partial resolution' method of Horeau. The biosynthetic pathway leading to d±plodiatoxin was investigated by incorporation studies with 13 c-, 2 H and 18 0-labelled precursors. | |
dc.description.degree | MSc (Chemistry) | |
dc.description.department | Chemistry | |
dc.identifier.uri | http://hdl.handle.net/2263/99617 | |
dc.language.iso | en | |
dc.publisher | University of Pretoria | |
dc.rights | © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. | |
dc.subject | Isolation | |
dc.subject | Structure | |
dc.subject | Metabolites | |
dc.subject | Diplodia maydis | |
dc.subject | UCTD | |
dc.title | Isolation and structure of the metabolites from diplodia maydis | |
dc.type | Dissertation |