dc.contributor.author |
Chandler, Jennifer C.
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dc.contributor.author |
Jafree, Daniyal J.
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dc.contributor.author |
Malik, Saif
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dc.contributor.author |
Pomeranz, Gideon
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dc.contributor.author |
Ball, Mary
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dc.contributor.author |
Kolatsi-Joannou, Maria
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dc.contributor.author |
Piapi, Alice
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dc.contributor.author |
Mason, William J.
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dc.contributor.author |
Benest, Andrew V.
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dc.contributor.author |
Bates, David O.
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dc.contributor.author |
Letunovska, Aleksandra
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dc.contributor.author |
Al-Saadi, Reem
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dc.contributor.author |
Rabant, Marion
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dc.contributor.author |
Boyer, Olivia
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dc.contributor.author |
Pritchard-Jones, Kathy
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dc.contributor.author |
Winyard, Paul J.
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dc.contributor.author |
Mason, Andrew S.
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dc.contributor.author |
Woolf, Adrian S.
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dc.contributor.author |
Waters, Aoife M.
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dc.contributor.author |
Long, David A.
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dc.date.accessioned |
2024-10-31T07:28:20Z |
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dc.date.available |
2024-10-31T07:28:20Z |
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dc.date.issued |
2024-10 |
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dc.description |
DATA AVAILABILITY STATEMENT :
Primary sequencing data reported in this paper are available on NCBI Sequence Read Archive (SRA PRJNA928337). Processed data for scRNA-seq experiments are available on Zenodo at DOI: 10.5281/zenodo.7565867.
The codes generated during this study are available at Github repository https://github.com/daniyal-jafree1995/collaborations. All other unique reagents used in this study are available from the corresponding author on reasonable request. |
en_US |
dc.description |
SUPPLEMENTARY MATERIALS AND METHODS : FIGURE S1. Supporting data for single-cell RNA seq analyses.
FIGURE S2. Characterisation of primary cell lines.
FIGURE S3. Isolation of podocytes from scRNA-seq data from additional murine models of glomerular disease for cross-disease comparison.
FIGURE S4. Dysregulated genes shown by individual sample for each human glomerular pathology (source Nephroseq).
TABLE S1. Differentially expressed genes in glomerular cells in Wt1R394W/+ mice.
TABLE S2. Podocyte differentially expressed genes that are conserved across murine glomerular scRNA-seq datasets or unique to Wt1R394W/+.
TABLE S3. Podocyte differentially expressed genes classified in ‘GO:0002376 – immune system process’ across murine glomerular scRNA-seq datasets. |
en_US |
dc.description.abstract |
Please read abstract in the article. |
en_US |
dc.description.department |
Medical Oncology |
en_US |
dc.description.librarian |
hj2024 |
en_US |
dc.description.sdg |
SDG-03:Good heatlh and well-being |
en_US |
dc.description.sponsorship |
LifeArc/Great Ormond Street Children's Charity;
Medical Research Centre;
Kidney Research UK;
British Heart Foundation;
Diabetes UK;
Wellcome Trust. |
en_US |
dc.description.uri |
https://onlinelibrary.wiley.com/journal/10969896 |
en_US |
dc.identifier.citation |
Chandler J.C., Jafree D.J., Malik S. et al. 2024, 'Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease', Journal of Pathology, vol. 264, no. 2, pp. 212-227, doi : 10.1002/path.6339. |
en_US |
dc.identifier.issn |
0022-3417 (print) |
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dc.identifier.issn |
1096-9896 (online) |
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dc.identifier.other |
10.1002/path.6339 |
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dc.identifier.uri |
http://hdl.handle.net/2263/98857 |
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dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.rights |
© 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
This is an open access article under the terms of the Creative Commons Attribution License. |
en_US |
dc.subject |
Vascular endothelial growth factor-A |
en_US |
dc.subject |
WT1 glomerulopathy |
en_US |
dc.subject |
Wilms tumour 1 (WT1) |
en_US |
dc.subject |
Single-cell transcriptomics |
en_US |
dc.subject |
Podocyte |
en_US |
dc.subject |
Neuropilin-1 |
en_US |
dc.subject |
Glomerular endothelium |
en_US |
dc.subject |
Childhood glomerular disease |
en_US |
dc.subject |
Adrenomedullin |
en_US |
dc.subject |
SDG-03: Good health and well-being |
en_US |
dc.title |
Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease |
en_US |
dc.type |
Article |
en_US |