Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis

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dc.contributor.author Tlaamela, Dikonketso
dc.contributor.author Mahlo, Salome M.
dc.contributor.author McGaw, Lyndy Joy
dc.date.accessioned 2024-10-30T12:00:29Z
dc.date.available 2024-10-30T12:00:29Z
dc.date.issued 2024-07
dc.description DATA AVAILABILITY : The data used to support the findings of this study may be released upon application to the corresponding author, S.M. en_US
dc.description.abstract BACKGROUND : Oral candidiasis is caused by Candida albicans, which is most prevalent in immunocompromised patients. AIM : The study aimed to investigate the antifungal activity of plant species used for oral candidiasis against C. albicans. SETTING : The study was conducted in Aganang Local Municipality, Capricorn District, Limpopo province, South Africa. METHODS : A survey was conducted using a semi-structured questionnaire supplemented with guided field walks with traditional health practitioners to gather information on medicinal plants used to treat oral candidiasis. Nine plant species (Artemisia afra Jacq. ex Willd., Blepharis subvolubilis subsp. subvolubilis C.B. Clarke, Enicostemma axillare [Lam.], Helichrysum caespititium [DC.] Harv., Solanum incanum L., Waltheria indica L., Ximenia caffra Sond. var. caffra, Ximenia caffra Sond. var. natalensis and Ziziphus mucronata Willd.) were investigated for antifungal activity. The plant material were extracted with solvents of varying polarities: acetone, dichloromethane, ethyl acetate, ethanol, hexane, methanol, and water. The Micro-dilution and bioautography assays were used to determine the antifungal activity of the plant extracts. RESULTS : Leaf extracts of A. afra and S. incanum were more active against C. albicans with MIC values of 0.02 mg/mL. Bioautography assay demonstrated active compounds in S. incanum, W. indica and X. caffra var. caffra extracts developed in Benzene: Ethanol: Ammonia hydroxide (BEA). CONCLUSION : An ethnobotanical survey is a worthy starting point in selecting potential plant species for ethnopharmacological studies. CONTRIBUTION : The effectiveness of oral administrations of the medicinal plants was confirmed by the excellent antifungal activity of the aqueous extracts. en_US
dc.description.department Paraclinical Sciences en_US
dc.description.librarian hj2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The National Research Foundation (NRF). en_US
dc.description.uri http://www.jomped.org/ en_US
dc.identifier.citation Tlaamela, D., Mahlo, S. & McGaw, L., 2024, ‘Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis’, Journal of Medicinal Plants for Economic Development 8(1), a220. https://doi.org/10.4102/jomped.v8i1.220. en_US
dc.identifier.issn 2519-559X (print)
dc.identifier.issn 2616-4809 (online)
dc.identifier.other 10.4102/jomped.v8i1.220
dc.identifier.uri http://hdl.handle.net/2263/98848
dc.language.iso en en_US
dc.publisher AOSIS en_US
dc.rights © 2024. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. en_US
dc.subject Medicinal plants en_US
dc.subject Candidiasis en_US
dc.subject Ethnobotanical survey en_US
dc.subject Antifungal activity en_US
dc.subject Minimum inhibitory concentration (MIC) en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis en_US
dc.type Article en_US


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