Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals
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| dc.contributor.author | Salvador-Oke, Kafilat Taiwo
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| dc.contributor.author | Pitout, Johann D.D.
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| dc.contributor.author | Peirano, Gisele
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| dc.contributor.author | Strydom, Kathy-Anne
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| dc.contributor.author | Kingsburgh, Chanel
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| dc.contributor.author | Ehlers, Marthie Magdaleen
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| dc.contributor.author | Kock, Marleen M.
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| dc.date.accessioned | 2024-10-22T06:34:07Z | |
| dc.date.available | 2024-10-22T06:34:07Z | |
| dc.date.issued | 2024-11 | |
| dc.description | DATA AVAILABILITY : No datasets were generated or analysed during the current study. | en_US |
| dc.description.abstract | This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with blaOXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring blaOXA-48-like including blaOXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies. | en_US |
| dc.description.department | Medical Microbiology | en_US |
| dc.description.librarian | hj2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | The National Research Foundation (NRF) of South Africa; Competitive Support for Unrated Researchers and the University of Pretoria (PhD student bursary, 2022). Open access funding provided by University of Pretoria. | en_US |
| dc.description.uri | https://link.springer.com/journal/10096 | en_US |
| dc.identifier.citation | Salvador-Oke, K.T., Pitout, J.D.D., Peirano, G. et al. Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaOXA181 in South African community hospitals. European Journal of Clinical Microbiology & Infectious Diseases 43, 2239–2244 (2024). https://doi.org/10.1007/s10096-024-04947-z. | en_US |
| dc.identifier.issn | 0934-9723 (print) | |
| dc.identifier.issn | 1435-4373 (online) | |
| dc.identifier.other | 10.1007/s10096-024-04947-z | |
| dc.identifier.uri | http://hdl.handle.net/2263/98695 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.rights | © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
| dc.subject | Klebsiella pneumoniae | en_US |
| dc.subject | Gauteng Province, South Africa | en_US |
| dc.subject | Extensively drug resistant (XDR) | en_US |
| dc.subject | Carbapenemase-producing Klebsiella pneumoniae | en_US |
| dc.subject | High-risk clone ST307 | en_US |
| dc.subject | IncX3 plasmid | en_US |
| dc.subject | bla OXA-181 | en_US |
| dc.subject | Low- and middle-income countries (LMICs) | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals | en_US |
| dc.type | Article | en_US |
