Spillover of an endemic avian Influenza H6N2 chicken lineage to ostriches and reassortment with clade 2.3.4.4b H5N1 high pathogenicity viruses in chickens

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dc.contributor.author Abolnik, Celia
dc.date.accessioned 2024-09-17T04:48:36Z
dc.date.available 2024-09-17T04:48:36Z
dc.date.issued 2024-04
dc.description DATA AVAILABILITY : All sequences generated in this study are available in the GISAID EpiFlu database. en_US
dc.description.abstract Prior to 2017, chicken production in South Africa had only ever been affected by an endemic strain of H6N2 low pathogenic avian influenza (LPAI), but since 2017, an outbreak of Goose/Guangdong clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) introduced by wild birds, followed by clade 2.3.4.4b H5N1 HPAI (2021-present), affected the country. In the present study, the viruses from seven cases of H6N2 LPAI from commercial poultry between October 2019 and August 2020 were genome-sequenced along with an H5N2 HPAI virus, and phylogenetic analysis was performed. The H5N2 HPAI virus caused localized outbreaks in a small-scale chicken farm and a large commercial layer farm in the KwaZulu-Natal province between late October and early December 2022. The phylogenetic results confirmed the first incidence of the chicken-adapted H6N2 lineage in commercial ostriches in the Western Cape province, with a likely epidemiological origin in chickens from the KwaZulu Natal province. The results also showed that the H5N2 HPAI virus was a novel reassortant of PB2, PB1, PA, NP and NA genome segments derived from a parental H6N2 virus that circulated in region, whereas the HA, M and NS genome segments were derived from sub-genotype SA10 H5N1 HPAI parental virus that had circulated in the local wild bird reservoir since July 2021. en_US
dc.description.department Production Animal Studies en_US
dc.description.librarian hj2024 en_US
dc.description.sdg SDG-02:Zero Hunger en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The Department of Science and Innovation/ National Research Foundation. Open access funding provided by University of Pretoria. en_US
dc.description.uri http://link.springer.com/journal/11259 en_US
dc.identifier.citation Abolnik, C. Spillover of an endemic avian Influenza H6N2 chicken lineage to ostriches and reassortment with clade 2.3.4.4b H5N1 high pathogenicity viruses in chickens. Veterinary Research Communications 48, 1233–1237 (2024). https://doi.org/10.1007/s11259-023-10258-z. en_US
dc.identifier.issn 0165-7380 (print)
dc.identifier.issn 1573-7446 (online)
dc.identifier.other 10.1007/s11259-023-10258-z
dc.identifier.uri http://hdl.handle.net/2263/98236
dc.language.iso en en_US
dc.publisher Springer en_US
dc.rights © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. en_US
dc.subject Avian influenza virus (AIV) en_US
dc.subject H6N2 en_US
dc.subject High pathogenicity avian influenza (HPAI) en_US
dc.subject H5N1 en_US
dc.subject Genome sequencing en_US
dc.subject Reassortment en_US
dc.subject SDG-03: Good health and well-being en_US
dc.subject SDG-02: Zero hunger en_US
dc.title Spillover of an endemic avian Influenza H6N2 chicken lineage to ostriches and reassortment with clade 2.3.4.4b H5N1 high pathogenicity viruses in chickens en_US
dc.type Article en_US


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