Abstract:
Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that
lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by
Wnt, Notch, TGF-beta, and VEGF pathway activation, which leads to cell invasion and metastasis.
To address this, the use of phytochemicals as a therapeutic option for TNBC has been researched.
Plants contain natural compounds known as phytochemicals. Curcumin, resveratrol, and EGCG are
phytochemicals that have been found to inhibit the pathways that cause TNBC, but their limited
bioavailability and lack of clinical evidence for their use as single therapies pose challenges to
the use of these phytochemical therapies. More research is required to better understand the role
of phytochemicals in TNBC therapy, or to advance the development of more effective delivery
mechanisms for these phytochemicals to the site where they are required. This review will discuss
the promise shown by phytochemicals as a treatment option for TNBC.
