Structural gonadal lesions observed in Japanese quail (Coturnix coturnix japonica) following exposure during puberty to the neonicotinoid pesticide, imidacloprid

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dc.contributor.author Ibrahim, M.I.A.
dc.contributor.author Lensink, Antonia Vergina
dc.contributor.author Phaswane, Rephima M.
dc.contributor.author Botha, C.J. (Christoffel Jacobus)
dc.date.accessioned 2024-09-13T04:59:45Z
dc.date.available 2024-09-13T04:59:45Z
dc.date.issued 2024-08
dc.description DATA AVAILABILITY : Data will be made available on request. en_US
dc.description.abstract Exposure to the neonicotinoid insecticide, imidacloprid (IMI), causes reproductive toxicity in mammals and reptiles. However, reports on the effects of IMI on the gonads in birds are grossly lacking. Therefore, this study investigated the effects of pubertal exposure to IMI on the histology, ultrastructure, as well as the cytoskeletal proteins, desmin, smooth muscle actin and vimentin, of the gonads of Japanese quail (Coturnix coturnix japonica). Quails were randomly divided into four groups at 5 weeks of age. The control group was given only distilled water, whereas, the other three experimental groups, IMI was administered by oral gavage at 1.55, 3.1, and 6.2 mg/kg, twice per week for 4 weeks. Exposure to IMI doses of 3.1 and 6.2 mg/kg caused dose-dependent histopathological changes in the ovary and testis. In the ovary, accumulation of lymphocytes, degenerative changes, and necrosis with granulocyte infiltrations were observed, while in the testis, distorted seminiferous tubules, germ cell sloughing, vacuolisations, apoptotic bodies, autophagosomes, and mitochondrial damage were detected. These changes were accompanied by a decreased number of primary follicles (P ≤ 0.05) in the ovary and a decrease (P ≤ 0.05) in the epithelial height, luminal, and tubular diameters of seminiferous tubules at the two higher dosages. In addition, IMI had a negative effect on the immunostaining intensity of desmin, smooth muscle actin, and vimentin in the ovarian and testicular tissue. In conclusion, exposure to IMI during puberty can lead to a range of histopathological alterations in the gonads of Japanese quails, which may ultimately result in infertility. en_US
dc.description.department Anatomy and Physiology en_US
dc.description.department Paraclinical Sciences en_US
dc.description.librarian hj2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The University of Pretoria as part of the Co-funded Post-Doctoral Fellowship program. en_US
dc.description.uri https://www.elsevier.com/locate/tice en_US
dc.identifier.citation Ibrahim, M.I.A., Lensink, A.V., Phaswane, R.M. & Botha, C.J. 2024, 'Structural gonadal lesions observed in Japanese quail (Coturnix coturnix japonica) following exposure during puberty to the neonicotinoid pesticide, imidacloprid', Tissue and Cell, vol. 89, art. 102450, pp. 1-14, doi : 10.1016/j.tice.2024.102450. en_US
dc.identifier.issn 0040-8166 (print)
dc.identifier.issn 1532-3072 (online)
dc.identifier.uri http://hdl.handle.net/2263/98170
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by- nc/4.0/). en_US
dc.subject Neonicotinoid insecticide en_US
dc.subject Imidacloprid (IMI) en_US
dc.subject Reproductive toxicity en_US
dc.subject Japanese quail (Coturnix coturnix japonica) en_US
dc.subject Ovary en_US
dc.subject Testis en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Structural gonadal lesions observed in Japanese quail (Coturnix coturnix japonica) following exposure during puberty to the neonicotinoid pesticide, imidacloprid en_US
dc.type Article en_US


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