The diverse pathogenicity of various Babesia parasite species that infect dogs

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dc.contributor.author Leisewitz, Andrew L.
dc.contributor.author Mrljak, Vladimir
dc.contributor.author Dear, Jonathan D.
dc.contributor.author Birkenheuer, Adam
dc.date.accessioned 2024-09-10T12:22:05Z
dc.date.available 2024-09-10T12:22:05Z
dc.date.issued 2023-12-11
dc.description DATA AVAILABILITY STATEMENT : No new data were created or analyzed in this study. Data sharing is not applicable to this article. en_US
dc.description.abstract Babesia species infect a very wide range of mammal hosts across the globe, and zoonotic infections are of growing concern. Several species of the Babesia genus infect dogs, and some of these cause significant morbidity and mortality. The Apicomplexan parasite resides within the red cell and infections result in direct damage to the host through intra- and extravascular hemolysis. An exuberant inflammatory response by the host to some species of Babesia parasites also results in significant collateral damage to the host. Canine infections have been the subject of many studies as the well-being of these companion animals is increasingly threatened by the spread of tick vectors and an increasingly mobile dog population. There are currently no widely available and effective vaccines, and effective treatment can be challenging. Understanding disease pathogenesis underlies the development of new treatments. The varying pathogenicity of the various Babesia parasite species that infect dogs offers an opportunity to explore the molecular basis for the wide range of diseases caused by infection with this parasite genus. In this review, we focus on what has been reported about the clinical presentation of Babesia-infected dogs in an attempt to compare the severity of disease caused by different Babesia species. en_US
dc.description.department Companion Animal Clinical Studies en_US
dc.description.librarian am2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.uri https://www.mdpi.com/journal/pathogens en_US
dc.identifier.citation Leisewitz, A.L.; Mrljak, V.; Dear, J.D.; Birkenheuer, A. The Diverse Pathogenicity of Various Babesia Parasite Species That Infect Dogs. Pathogens 2023, 12, 1437. https://doi.org/10.3390/pathogens12121437. en_US
dc.identifier.issn 2076-0817 (online)
dc.identifier.other 10.3390/pathogens12121437
dc.identifier.uri http://hdl.handle.net/2263/98112
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. en_US
dc.subject Babesiosis en_US
dc.subject Canine en_US
dc.subject Babesia rossi en_US
dc.subject Babesia canis en_US
dc.subject Babesia gibsoni en_US
dc.subject Babesia vogeli en_US
dc.subject Babesia conradae en_US
dc.subject Disease comparison en_US
dc.subject Dogs (Canis familiaris) en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title The diverse pathogenicity of various Babesia parasite species that infect dogs en_US
dc.type Article en_US


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