Abstract:
Undetected and unmonitored hypertension carries substantial mortality and morbidity, especially during pregnancy. We assessed
the accuracy of OptiBPTM, a smartphone application for estimating blood pressure (BP), across diverse settings. The study was
conducted in community settings: Gaibandha, Bangladesh and Ifakara, Tanzania for general populations, and Kalafong Provincial
Tertiary Hospital, South Africa for pregnant populations. Based on guidance from the International Organization for Standardization
(ISO) 81,060–2:2018 for non-invasive BP devices and global consensus statement, we compared BP measurements taken by two
independent trained nurses on a standard auscultatory cuff to the BP measurements taken by a research version of OptiBPTM called
CamBP. For ISO criterion 1, the mean error was 0.5 ± 5.8mm Hg for the systolic blood pressure (SBP) and 0.1 ± 3.9 mmHg for the
diastolic blood pressure (DBP) in South Africa; 0.8 ± 7.0 mmHg for the SBP and −0.4 ± 4.0 mmHg for the DBP in Tanzania;
3.3 ± 7.4 mmHg for the SBP and −0.4 ± 4.3 mmHg for the DBP in Bangladesh. For ISO criterion 2, the average standard deviation of
the mean error per subject was 4.9 mmHg for the SBP and 3.4 mmHg for the DBP in South Africa; 6.3 mmHg for the SBP and
3.6 mmHg for the DBP in Tanzania; 6.4 mmHg for the SBP and 3.8 mmHg for the DBP in Bangladesh. OptiBPTM demonstrated
accuracy against ISO standards in study populations, including pregnant populations, except in Bangladesh for SBP (criterion 2).
Further research is needed to improve performance across different populations and integration within health systems.
Description:
DATA AVAILABILITY :
All study materials will be available upon request. Anonymized data will be made
available towards regulatory approval after publication of findings with permission
from country teams. Access to de-identified dataset and study materials, including
the protocol, statistical analysis plan, and case reporting forms, may be made
available based on email request to SRHHRP@who.int, using a data agreement;
please indicate “CamBP research study” in the subject line.
CODE AVAILABILITY :
The statistical code for analysis may be made available based on email request to
SRHHRP@who.int, using a code availability agreement; please indicate “CamBP
research study” in the subject line.