Left ventricular trabeculation in Hominidae : divergence of the human cardiac phenotype

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dc.contributor.author Curry, Bryony A.
dc.contributor.author Drane, Aimee L.
dc.contributor.author Atencia, Rebeca
dc.contributor.author Feltrer, Yedra
dc.contributor.author Calvi, Thalita
dc.contributor.author Milnes, Ellie L.
dc.contributor.author Moittie, Sophie
dc.contributor.author Weigold, Annika
dc.contributor.author Knauf-Witzens, Tobias
dc.contributor.author Sawung Kusuma, Arga
dc.contributor.author Howatson, Glyn
dc.contributor.author Palmer, Christopher
dc.contributor.author Stembridge, Mike R.
dc.contributor.author Gorzynski, John E.
dc.contributor.author Eves, Neil D.
dc.contributor.author Dawkins, Tony G.
dc.contributor.author Shave, Rob E.
dc.date.accessioned 2024-08-28T06:52:35Z
dc.date.available 2024-08-28T06:52:35Z
dc.date.issued 2024-06
dc.description DATA AVAILABILITY : The data that support the findings of this study are available in Figshare repository with the identifiers: https://doi.org/10.6084/m9.figshare.24274852 and https://doi.org/10.6084/m9.figshare.24274855. en_US
dc.description.abstract Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche. en_US
dc.description.department Centre for Veterinary Wildlife Studies en_US
dc.description.librarian hj2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The Natural Sciences and Engineering Research Council and the Canadian Foundation for Innovation. en_US
dc.description.uri https://www.nature.com/commsbio/ en_US
dc.identifier.citation Curry, B.A., Drane, A.L., Atencia, R. et al. Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype. Communications Biology 7, 682 (2024). https://doi.org/10.1038/s42003-024-06280-9. en_US
dc.identifier.issn 2399-3642 (online)
dc.identifier.other 10.1038/s42003-024-06280-9
dc.identifier.uri http://hdl.handle.net/2263/97900
dc.language.iso en en_US
dc.publisher Nature Research en_US
dc.rights © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License. en_US
dc.subject Cardiovascular biology en_US
dc.subject Biological anthropology en_US
dc.subject Cardiac phenotype en_US
dc.subject Left ventricular trabeculation en_US
dc.subject Hominidae en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Left ventricular trabeculation in Hominidae : divergence of the human cardiac phenotype en_US
dc.type Article en_US


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