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dc.contributor.author | Mfangnia, Charlene N.T.![]() |
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dc.contributor.author | Tonnang, Henri E.Z.![]() |
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dc.contributor.author | Tsanou, Berge![]() |
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dc.contributor.author | Herren, Jeremy![]() |
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dc.date.accessioned | 2024-08-22T10:52:26Z | |
dc.date.available | 2024-08-22T10:52:26Z | |
dc.date.issued | 2023-07-18 | |
dc.description | AVAILABILITY OF DATA AND MATERIALS : All data generated or analysed during this study are included in this published article. | en_US |
dc.description | The present study was executed by the International Centre of Insect Physiology and Ecology as part of the Symbiont Modeling and Deployment Strategies project, made possible by the generous support of the Bill and Melinda Gates Foundation. | en_US |
dc.description.abstract | A recent discovery highlighted that mosquitoes infected with Microsporidia MB are unable to transmit the Plasmodium to humans. Microsporidia MB is a symbiont transmitted vertically and horizontally in the mosquito population, and these transmission routes are known to favor the persistence of the parasite in the mosquito population. Despite the dual transmission, data from field experiments reveal a low prevalence of MB-infected mosquitoes in nature. This study proposes a compartmental model to understand the prevalence of MB-infected mosquitoes. The dynamic of the model is obtained through the computation of the basic reproduction number and the analysis of the stability of the MB-free and coexistence equilibria. The model shows that, in spite of the high vertical transmission efficiency of Microsporidia MB, there can still be a low prevalence of MB-infected mosquitoes. Numerical analysis of the model shows that male-to-female horizontal transmission contributes more than female-to-male horizontal transmission to the spread of MB-infected mosquitoes. Moreover, the female-to-male horizontal transmission contributes to the spread of the symbiont only if there are multiple mating occurrences for male mosquitoes. Furthermore, when fixing the efficiencies of vertical transmission, the parameters having the greater influence on the ratio of MB-positive to wild mosquitoes are identified. In addition, by assuming a similar impact of the temperature on wild and MB-infected mosquitoes, our model shows the seasonal fluctuation of MB-infected mosquitoes. This study serves as a reference for further studies, on the release strategies of MB-infected mosquitoes, to avoid overestimating the MB-infection spread. | en_US |
dc.description.department | Mathematics and Applied Mathematics | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.uri | http://www.aimspress.com/journal/mbe | en_US |
dc.identifier.citation | Mfangnia, C.N.T., Tonnang, H.E.Z., Tsanou, B. et al. 2023, 'Mathematical modelling of the interactive dynamics of wild and Microsporidia MB-infected mosquitoes', Mathematical Biosciences and Engineering, vol. 20, no. 8, pp. 15167-15200. DOI: 10.3934/mbe.2023679. | en_US |
dc.identifier.issn | 1547-1063 (print) | |
dc.identifier.issn | 1551-0018 (print) | |
dc.identifier.other | 10.3934/mbe.2023679 | |
dc.identifier.uri | http://hdl.handle.net/2263/97816 | |
dc.language.iso | en | en_US |
dc.publisher | AIMS Press | en_US |
dc.rights | © 2023 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License. | en_US |
dc.subject | Microsporidia MB | en_US |
dc.subject | Plasmodium transmission-blocking | en_US |
dc.subject | Vertical-horizontal transmission | en_US |
dc.subject | Compartmental modelling | en_US |
dc.subject | Seasonality | en_US |
dc.subject | Malaria bio-control | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Mathematical modelling of the interactive dynamics of wild and Microsporidia MB-infected mosquitoes | en_US |
dc.type | Article | en_US |