Poikilocytosis of Angora goats is associated with erythrocyte density and reticulocytosis

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dc.contributor.author Parsons, S.D.C.
dc.contributor.author Becks, D.
dc.contributor.author Vermeulen, A.
dc.contributor.author Hobson, M.
dc.contributor.author Warren, R.M.
dc.contributor.author Hooijberg, Emma Henriette
dc.date.accessioned 2024-08-15T10:55:52Z
dc.date.available 2024-08-15T10:55:52Z
dc.date.issued 2023-02
dc.description.abstract Angora goats in South Africa experience several syndromes that result in notable morbidity and mortality in juveniles and adults, but not kids. Insight into their causes is hampered by the lack of normal reference values for this breed, and the present study therefore aimed to characterise (1) differences in the haematology of healthy kids at birth and weaning, and (2) the haematology of apparently healthy yearlings. Selected variables were measured by blood smear analysis, and complete blood counts were performed using an ADVIA 2120i. Variables at 1, 11, and 20 weeks of age were compared using the Friedman test and associations between variables of yearlings were determined by correlation analysis. In kids, red blood cell count, mean corpuscular haemoglobin concentration (MCHC), and poikilocytosis increased over time, while mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV) decreased. Yearlings displayed a lower MCHC, and higher haemoglobin distribution width than previously reported for goats, and these were positively correlated with poikilocytosis, as were reticulocyte counts. White cell counts of yearlings exceeded normal values previously reported for goats, with some individuals displaying remarkably high mature neutrophil counts. Changes in haemoglobin variant expression or cation and water fluxes are possible explanations for the findings in kids, while in yearlings, the associations between MCHC, HDW, poikilocytosis, and reticulocytosis suggest alterations in red cell hydration in adulthood that are associated with increased red cell turnover. These findings may prove informative in the further investigation of various clinical syndromes in this population. en_US
dc.description.department Companion Animal Clinical Studies en_US
dc.description.librarian am2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sponsorship The South African Medical Research Council (SAMRC) Centre for Tuberculosis Research; The Harry Crossley Foundation; The Faculty of Medicine and Health Sciences Undergraduate Research Project Fund of Stellenbosch University. en_US
dc.description.uri http://www.jsava.co.za en_US
dc.identifier.citation Parsons, S.D.C., Becks, D., Vermeulen, A. et al. 2023, 'Poikilocytosis of Angora goats is associated with erythrocyte density and reticulocytosis', Journal of the South African Veterinary Association, vol. 94. no. 1, pp. 42-53. https://DOI.org/10.36303/JSAVA.547. en_US
dc.identifier.issn 2224-9435 (print)
dc.identifier.issn 1019-9128 (online)
dc.identifier.other 10.36303/JSAVA.547
dc.identifier.uri http://hdl.handle.net/2263/97663
dc.language.iso en en_US
dc.publisher MedPharm Publications en_US
dc.rights © 2023 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0]. en_US
dc.subject Angora goat en_US
dc.subject Mean corpuscular haemoglobin concentration (MCHC) en_US
dc.subject Mean corpuscular volume (MCV) en_US
dc.subject Poikilocytosis en_US
dc.subject Reticulocytosis en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Poikilocytosis of Angora goats is associated with erythrocyte density and reticulocytosis en_US
dc.type Article en_US


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