Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)

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dc.contributor.author Roug, Annette
dc.contributor.author Smith, C.
dc.contributor.author Raath, J.P.
dc.contributor.author Meyer, Leith Carl Rodney
dc.contributor.author Laubscher, L.L.
dc.date.accessioned 2024-08-15T10:19:34Z
dc.date.available 2024-08-15T10:19:34Z
dc.date.issued 2023-02
dc.description.abstract African wildlife species are increasingly being immobilised with combinations of a low dose of potent opioids combined with medetomidine and azaperone. The physiological effects of these combinations in comparison to conventional potent opioidazaperone combinations have scarcely been evaluated. In this cross-over study conducted on eight captive blesbok, we compared the physiological variables of blesbok immobilised with 2 mg of thiafentanil + 10 mg of azaperone (TA); 0.5 mg thiafentanil + 1.5 mg medetomidine (TM), and 0.5 mg thiafentanil + 1.5. mg medetomidine + 10 mg azaperone (TMA). Thiafentanil’s effects were antagonised with naltrexone at 10 mg naltrexone per mg thiafentanil, and the medetomidine effects with atipamezole at 5 mg atipamezole per mg medetomidine. The physiological variables were compared between treatment groups using descriptive statistics and repeated measures ANOVA. The TA combination resulted in the shortest induction and recovery times, higher heart rates, respiratory rates, PaO2, SpO2, and lower MAP and A-a gradients, but with less muscle relaxation. The TM and TMA combinations caused marked bradycardia and hypoxaemia. The hypoxaemia was most severe in animals immobilised with TMA, and four of eight blesbok immobilised had a PaO2 < 35 mmHg at the 10- or 15-minute sampling point. These blesbok were provided supplementary oxygen, which corrected the hypoxaemia. The TA combinations caused the lowest degree of physiological compromise. All three combinations were effective for the immobilisation of blesbok, but as the low-dose thiafentanil and high-dose medetomidine combinations caused marked hypoxaemia, supplementary oxygen is recommended when using these combinations. en_US
dc.description.department Centre for Veterinary Wildlife Studies en_US
dc.description.department Paraclinical Sciences en_US
dc.description.department Production Animal Studies en_US
dc.description.librarian am2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.sdg SDG-15:Life on land en_US
dc.description.sponsorship An American Association of Zoo Veterinarians (AAZV) Wild Animal Health Fund grant and the facility and equipment provided by Wildlife Pharmaceuticals South Africa (Pty) Ltd, and the University of Pretoria. en_US
dc.description.uri http://www.jsava.co.za en_US
dc.identifier.citation Roug, A., Smith, C., Raath, J.P. 2023, 'Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi)', Journal of the South African Veterinary Association, vol. 94, no. 1, pp. 145-152. https://DOI.org/10.36303/JSAVA.567. en_US
dc.identifier.issn 2224-9435 (print)
dc.identifier.issn 1019-9128 (online)
dc.identifier.other 10.36303/JSAVA.567
dc.identifier.uri http://hdl.handle.net/2263/97659
dc.language.iso en en_US
dc.publisher MedPharm Publications en_US
dc.rights © 2023 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC 3.0] en_US
dc.subject Thiafentanil en_US
dc.subject Medetomidine en_US
dc.subject Azaperone en_US
dc.subject Chemical immobilisation en_US
dc.subject Hypoxaemia en_US
dc.subject Blesbok (Damaliscus pygargus phillipsi) en_US
dc.subject SDG-03: Good health and well-being en_US
dc.subject SDG-15: Life on land en_US
dc.title Efficacy and safety of three different opioid-based immobilisation combinations in blesbok (Damaliscus pygargus phillipsi) en_US
dc.type Article en_US


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