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dc.contributor.author | Hassan, Shereen![]() |
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dc.contributor.author | El Baradey, Hala![]() |
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dc.contributor.author | Madi, Mohamed![]() |
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dc.contributor.author | Shebl, Mohamed![]() |
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dc.contributor.author | Leng, Gareth![]() |
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dc.contributor.author | Lozic, Mala![]() |
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dc.contributor.author | Ludwig, Mike![]() |
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dc.contributor.author | Menzies, John![]() |
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dc.contributor.author | MacGregor, Duncan![]() |
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dc.date.accessioned | 2024-08-12T10:39:31Z | |
dc.date.available | 2024-08-12T10:39:31Z | |
dc.date.issued | 2023-06 | |
dc.description.abstract | In the present experiments, we tested the conclusion from previous electrophysiological experiments that gavage of sweet food and systemically applied insulin both stimulate oxytocin secretion. To do so, we measured oxytocin secretion from urethane-anaesthetised male rats, and demonstrated a significant increase in secretion in response to gavage of sweetened condensed milk but not isocaloric cream, and a significant increase in response to intravenous injection of insulin. We compared the measurements made in response to sweetened condensed milk with the predictions from a computational model, which we used to predict plasma concentrations of oxytocin from the published electrophysiological responses of oxytocin cells. The prediction from the computational model was very closely aligned to the levels of oxytocin measured in rats in response to gavage. | en_US |
dc.description.department | Immunology | en_US |
dc.description.librarian | am2024 | en_US |
dc.description.sdg | SDG-02:Zero Hunger | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sponsorship | This experimental work was funded by a BBSRC project grant and the modelling by a BBSRC project grant. Also funded by the Newton-Mosharafa Scholarship Fund from the Egyptian Ministry of Higher Education (Cultural Affairs and Mission Sector), the British Council, and the British Embassy in Egypt. | en_US |
dc.description.uri | http://wileyonlinelibrary.com/journal/jne | en_US |
dc.identifier.citation | Hassan, S., El Baradey, H., Madi, M., et al. Measuring oxytocin release in response to gavage: Computational modelling and assay validation. Journal of Neuroendocrinology 2023; 35 (6): e13303. DOI:10.1111/jne.13303. | en_US |
dc.identifier.issn | 0953-8194 (print) | |
dc.identifier.issn | 1365-2826 (online) | |
dc.identifier.other | 10.1111/jne.13303 | |
dc.identifier.uri | http://hdl.handle.net/2263/97562 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.rights | © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License. | en_US |
dc.subject | Appetite | en_US |
dc.subject | Computational modelling | en_US |
dc.subject | Hypothalamus | en_US |
dc.subject | Immunoassay | en_US |
dc.subject | Supraoptic nucleus | en_US |
dc.subject | SDG-02: Zero hunger | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | Measuring oxytocin release in response to gavage : computational modelling and assay validation | en_US |
dc.type | Article | en_US |