Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus)

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dc.contributor.author Mitchell, Emily P.
dc.contributor.author Henker, Melanie S.
dc.contributor.author Lemberger, Karin
dc.contributor.author Gohl, Christine
dc.contributor.author Majzoub-Altweck, Monir
dc.contributor.author Falkenau, Almuth
dc.contributor.author Caldwell, Peter
dc.contributor.author Chenet, Baptiste
dc.contributor.author Mosca, Marion
dc.contributor.author Pin, Didier
dc.contributor.author Denk, Daniela
dc.date.accessioned 2024-08-07T11:52:04Z
dc.date.available 2024-08-07T11:52:04Z
dc.date.issued 2023-11
dc.description AVAILABILITY OF DATA AND MATERIAL : Part of the case material included in the present study that derived from France was included in a poster presentation on familial occurrence of CATs in AWDs (cases 2, 9, 10 and 11) [19]. These cases and cases 3 and 8 were also included in a poster presentation as part of a retrospective study on neoplasms in AWDs in French zoological collections [7]. en_US
dc.description.abstract This retrospective study documents the occurrence of single and multiple cutaneous apocrine gland tumours (CATs) on the dorsal midline of 16 captive African wild dogs (AWDs, Lycaon pictus) derived from 161 submissions to diagnostic laboratories in South Africa, France and Germany between 1997 and 2022. Animals included in the study came from zoological institutions in South Africa (n ¼ 2), France (n ¼ 5) and Germany (n ¼ 1) and ranged from 5 to 14 years of age. Fifteen affected animals were female (94%) and one was male. CATs presented as raised, hairless, multilobular, grey firm masses, consistently located along the dorsal midline. Apart from a single cutaneous apocrine adenoma and a cystadenoma occurring concurrently with two non-cystic adenocarcinomas, neoplasms were consistent with malignant cutaneous apocrine adenocarcinomas with lymphatic spread and visceral metastases. Advanced age and female sex were identified as risk factors. A genetic component or association with the increasing use of GnRH agonist contraceptives was suspected but could not be established. This study highlights the need for close clinical monitoring of AWDs over the age of 5 years for the development of CATs along the dorsal midline and supports early surgical intervention. More research is needed to determine the role of inbreeding, endocrine changes and husbandry factors that may play a role in the development of CATs on the dorsal midline of AWDs. en_US
dc.description.department Centre for Veterinary Wildlife Studies en_US
dc.description.department Paraclinical Sciences en_US
dc.description.librarian am2024 en_US
dc.description.sdg SDG-03:Good heatlh and well-being en_US
dc.description.uri http://www.elsevier.com/locate/jcpa en_US
dc.identifier.citation Mitchell, E.P., Henker, M.S., Lemberger, K. et al. 2023, 'Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus)', Journal of Comparative Pathology, vol. 207, pp. 59-65. https://DOI.org/10.1016/j.jcpa.2023.10.005. en_US
dc.identifier.issn 0021-9975 (print)
dc.identifier.issn 1532-3129 (online)
dc.identifier.other 10.1016/j.jcpa.2023.10.005
dc.identifier.uri http://hdl.handle.net/2263/97495
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. en_US
dc.subject Dorsal midline en_US
dc.subject Lycaon pictus en_US
dc.subject Metastasis en_US
dc.subject Neoplasia en_US
dc.subject Skin en_US
dc.subject African wild dog (Lycaon pictus) en_US
dc.subject Cutaneous apocrine gland tumours (CATs) en_US
dc.subject Cutaneous apocrine adenocarcinoma en_US
dc.subject Adenoma en_US
dc.subject Cystadenoma en_US
dc.subject SDG-03: Good health and well-being en_US
dc.title Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus) en_US
dc.type Article en_US


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